Genomics and World Health : Report of the Advisory Committee on Health Research.

This report is intended to highlight the relevance of genomics (the study of genomes) for health care worldwide, with a particular focus on its potential for improving health in developing countries. The application of knowledge gained from the characterization of the genomes of several organisms, i...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Organization, World Health
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Geneva : World Health Organization, 2002.
Temas:
Genetics > Research > Moral and ethical aspects.
Genomes.
Medical care > Developing countries.
Génomes.
Genetics > Research > Moral and ethical aspects
Genomes
Medical care
Developing countries
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Contents
  • Executive Summary
  • 1. Introduction
  • 2. Genomics and the Genome Projects
  • 2.1 Introduction
  • 2.2 What are genes and how do they function?
  • 2.3 The development of molecular genetics
  • 2.3.1 Classical genetics
  • 2.3.2 Molecular genetics
  • 2.4 Characterizing the human genome
  • 2.4.1 The identification of human disease genes
  • 2.4.2 The Human Genome Project
  • 2.4.3 Mapping the human genome
  • 2.5 Functional genomics
  • 2.5.1 Annotation of the human genome
  • 2.5.2 Proteomics
  • 2.5.3 Transcriptomics
  • 2.5.4 Gene regulation
  • 2.5.5 Bioinformatics2.6 The genomes of other organisms
  • 2.6.1 Introduction
  • 2.6.2 The pathogen genome project
  • 2.6.3 The genomics of disease vectors
  • 2.6.4 The genomes of the worm, fruitfly, yeast and various animals
  • 2.6.5 The central importance of the mouse genome project
  • 2.6.6 Plant genomics
  • 2.7 Summary
  • 3. The Potential of Genomics for Health Care
  • 3.1 Introduction
  • 3.2 Monogenic disease
  • 3.3 Communicable disease
  • 3.4 Cancer
  • 3.5 Complex multifactorial disease
  • 3.6 Developmental abnormalities and mental retardation
  • 3.7 Ageing3.8 Pharmacogenomics
  • 3.9 Gene therapy
  • 3.10 Stem cell therapy
  • 3.11 Plant genomics and human health
  • 3.12 Forensic medicine
  • 3.13 Biotechnology
  • 3.14 Broader issues of biology
  • 3.15 Summary
  • 4. Relevance and Time-Scale of Advances in Genomics for Global Health
  • 4.1 Genomics in the context of current world health problems
  • 4.2 When will the medical promises of genomics be fulfilled?
  • 4.3 Maintaining the balance of research planning and health care
  • 4.4 Will the medical applications of genome research be affordable?
  • 4.5 Summary5. The Potential of Genomics for the Health of the Developing Countries
  • 5.1 Introduction
  • 5.2 Examples of what is feasible now
  • 5.2.1 The inherited disorders of hÃ?moglobin
  • 5.2.2 Genetic resistance to communicable disease
  • 5.2.3 The introduction of DNA diagnostics for communicable disease
  • 5.2.4 Drug-resistant organisms
  • 5.2.5 Pharmacogenomics
  • 5.2.6 Non-communicable disease
  • 5.3 The development and provision of services in clinical genetics and DNA technology
  • 5.4 Genomics for the control of communicable disease: future directions
  • 5.5 Forging international partnerships in academia5.6 Regional collaboration
  • 5.7 Information technology and bioinformatics
  • 5.8 Summary and future possibilities
  • 6. Potential Risks and Hazards of the Applications of Genomics and Their Control
  • 6.1 Introduction
  • 6.2 Genetic manipulation
  • 6.3 Risks in non-human genomics
  • 6.3.1 Animals and insects
  • 6.3.2 Plants
  • 6.4 Changing the genetic constitution of individuals or populations
  • 6.5 Genetic databases
  • 6.6 Biological warfare and other political misuses
  • 6.7 Stem cell gene therapy

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