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The Subthalamic Nucleus.
Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high freque...
| Clasificación: | Libro Electrónico |
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| Autores principales: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Guildford : Boulder :
Springer London NetLibrary, Inc. [distributor]
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| Colección: | Advances in Anatomy, Embryology and Cell Biology, 199.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1 Introduction; 2 The Basal Ganglia; 2.1 Pathways Within the Basal Ganglia; 2.2 Parkinson's Disease; 2.3 Deep Brain Stimulation; 3 STN Activity Recorded in Vitro: Brain Slices; 3.1 Spontaneous Activity; 3.2 Depolarizing and Hyperpolarizing Inputs; 3.3 Ionic Mechanisms of a Plateau Potential; 3.4 Synaptic Inputs; 3.5 High-Frequency Stimulation of STN Cells; 3.6 Intrinsic Versus Extrinsic Properties: Bursts; 4 STN Activity Recorded in Vitro: Dissociated Cell Cultures; 4.1 Experimental Set-up; 4.2 Spontaneous Activity; 4.3 Addition of Acetylcholine; 4.4 Electrical Stimulation.
- 5 STN Cell Models and Simulation of Neuronal Networks5.1 Otsuka's Model; 5.2 Terman and Rubin's Model; 5.3 Comparison of the Otsuka Model with the Terman/Rubin Model; 5.4 The Multi-compartment STN Model of Gillies and Willshaw; 5.5 Intra-nuclear Network Models; 5.6 Inter-nuclear Network Models; 6 Comparison of Part I and Part II; 6.1 Recurrent STN Axons; 6.2 Inter-neurons in the STN; 6.3 Fibre Tracts around and in the STN; 6.4 Ca 2+ Receptors; 6.5 Three-Dimensional Modelling; 6.6 Types of Projection Neurons; 6.7 Neurotransmitter Input Versus Receptors in the STN.
- 6.8 The Pedunculopontine Nucleus6.9 Nigro-subthalamic Connections; 6.10 Another Cortico-subthalamic Loop; 6.11 Nissl-Based Subdivision of the STN; Appendix 1 Model Parameter Values Otsuka et al. 2004; Appendix 2 Model Parameter Values Terman et al. 2002; Rubinand Terman (2004); References; Index.