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PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Michelson, Alan D.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Burlington, MA ; London, UK : Elsevier Academic Press, ©2007.
Edición:2nd ed.
Temas:
Blood platelets.
Blood Platelets
Sang > Plaquettes.
Blood platelets
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Front cover
  • Table of contents
  • Contributors
  • Preface
  • Foreword: A Brief History of Ideas about Platelets in Health and Disease
  • Part One: Platelet Biology
  • CHAPTER 1: The Evolution of Mammalian Platelets
  • I. Introduction
  • II. Invertebrates
  • III. Nonmammalian Vertebrates
  • IV. Comparative Hemostasis
  • V.A Comparison of Human Platelets and Limulus Amebocytes
  • VI. The Evolution of Hemostasis and Blood Coagulation
  • VII. Megakaryocytes and Mammals
  • VIII. Conclusions
  • Acknowledgment
  • References
  • CHAPTER 2: Megakaryocyte Development and Platelet Formation
  • I. Introduction
  • II. Megakaryocyte Development
  • III. Platelet Formation
  • IV. Regulation of Megakaryocyte Development and Platelet Formation
  • V. Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis
  • References
  • CHAPTER 3: Platelet Structure
  • I. Introduction
  • II. Peripheral Zone
  • III. The Sol-Gel Zone
  • IV. Organelle Zone
  • V. Platelet Membrane Systems
  • References
  • CHAPTER 4: The Platelet Cytoskeleton
  • I. Introduction
  • II. The Structure of the Resting Platelet
  • III. The Cytoskeleton of the Resting Platelet
  • IV. The Structure of the Activated Platelet
  • V. Signals Activating Actin Assembly
  • VI. Membrane Dynamics and Actin Filament Turnover in Platelets
  • VII. Platelet Contraction
  • VIII. Diseases of the Platelet Cytoskeleton
  • References
  • CHAPTER 5: Platelet Genomics and Proteomics
  • I. Introduction
  • II. Platelet Genomics
  • III. Platelet Proteomics
  • IV. Overview and Future Directions
  • Acknowledgment
  • References
  • CHAPTER 6: Platelet Receptors
  • I. Introduction
  • II. Integrins
  • III. Leucine-Rich Repeat (LRR) Family
  • IV. Seven Transmembrane Receptors
  • V. Immunoglobulin Superfamily
  • VI. C-Type Lectin Receptor Family
  • VII. Tetraspanins
  • VIII. Glycosyl Phosphatidylinositol (GPI)-Anchored Proteins
  • IX. Glycosaminoglycan-Carrying Receptors
  • X. Tyrosine Kinase Receptors
  • XI. Miscellaneous Platelet Membrane Glycoproteins
  • Acknowledgment
  • References
  • CHAPTER 7: The Glycoprotein Ib-IX-V Complex
  • I. Introduction/Structure
  • II. Function
  • III. Signaling
  • IV. The End of the Beginning
  • References
  • CHAPTER 8: Integrin a IIbb3
  • I. Introduction
  • II. aIIbb3 as an Integrin and a Platelet Protein
  • III. Structure of aIIbb3
  • IV. "Inside-Out" Signaling and aIIbb3 Activation
  • V. Conclusion
  • References
  • CHAPTER 9: Thrombin Receptors
  • I. Introduction
  • II. Cellular Actions of Thrombin
  • III. Role of PARs in Disease
  • IV. Molecular and Developmental Genetics of PARs
  • V. Thrombin Signaling in Platelets
  • VI. Development of PAR Inhibitors
  • References
  • CHAPTER 10: The Platelet P2 Receptors
  • I. Introduction
  • II. Roles of Adenine Nucleotides in Platelet Function
  • III. P2Y1
  • IV. P2Y12
  • V. P2X1
  • VI. Interplay between the Platelet P2 Receptors
  • VII. Desensitization of the Platelet P2 Receptors
  • VIII. Conclusions
  • T$7.

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