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Target Validation in Drug Discovery.
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics.
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Burlington :
Elsevier,
2006.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Title Page; Copyright Page; Table of Contents; Preface; Contributors; Chapter 1 Generation of Transgenic Animals; Chapter 2 Target Validation in Chemogenomics; Chapter 3 Cetuximab (Erbitux®), An Anti-Epidermal Growth Factor Receptor Antibody for the Treatment of Metastatic Colorectal Cancer; Chapter 4 Monoclonal Antibody to HER-2 in Breast Cancer; Chapter 5 Validation of TNF as a Drug Target in Inflammatory Bowel Disease; Chapter 6 Anti-CCL-2/MCP-1: Directed Biologicals for Inflammatory and Malignant Diseases; Chapter 7 Targeting IL-12p40 for Immune-Mediated Disease.
- Chapter 8 The GPIIb/IIIa Antagonist Abciximab for Acute Percutaneous Coronary InterventionChapter 9 Epidermal Growth Factor Receptor (EGFR) Inhibitor for Oncology: Discovery and Development of Erlotinib; Chapter 10 Progress in Achieving Proof of Concept for p38 Kinase Inhibitors; Chapter 11 IKK-2/NF-kappa B-Dependent Transcription; Chapter 12 TNF Signaling Pathway Inhibitors for Inflammation-CCR2 Antagonists; Cha.