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Target Validation in Drug Discovery.
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Burlington :
Elsevier,
2006.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Metcalf, Brian W. | |
| 245 | 1 | 0 | |a Target Validation in Drug Discovery. |
| 260 | |a Burlington : |b Elsevier, |c 2006. | ||
| 300 | |a 1 online resource (293 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 505 | 0 | |a Front Cover; Title Page; Copyright Page; Table of Contents; Preface; Contributors; Chapter 1 Generation of Transgenic Animals; Chapter 2 Target Validation in Chemogenomics; Chapter 3 Cetuximab (Erbitux®), An Anti-Epidermal Growth Factor Receptor Antibody for the Treatment of Metastatic Colorectal Cancer; Chapter 4 Monoclonal Antibody to HER-2 in Breast Cancer; Chapter 5 Validation of TNF as a Drug Target in Inflammatory Bowel Disease; Chapter 6 Anti-CCL-2/MCP-1: Directed Biologicals for Inflammatory and Malignant Diseases; Chapter 7 Targeting IL-12p40 for Immune-Mediated Disease. | |
| 505 | 8 | |a Chapter 8 The GPIIb/IIIa Antagonist Abciximab for Acute Percutaneous Coronary InterventionChapter 9 Epidermal Growth Factor Receptor (EGFR) Inhibitor for Oncology: Discovery and Development of Erlotinib; Chapter 10 Progress in Achieving Proof of Concept for p38 Kinase Inhibitors; Chapter 11 IKK-2/NF-kappa B-Dependent Transcription; Chapter 12 TNF Signaling Pathway Inhibitors for Inflammation-CCR2 Antagonists; Cha. | |
| 520 | |a This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. | ||
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references and index. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Drug development. | |
| 650 | 0 | |a Drugs |x Testing. | |
| 650 | 0 | |a High throughput screening (Drug development) | |
| 650 | 6 | |a Médicaments |x Développement. | |
| 650 | 6 | |a Médicaments |x Essais cliniques. | |
| 650 | 6 | |a Criblage à haut débit (Développement des médicaments) | |
| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Drugs |x Testing |2 fast | |
| 650 | 7 | |a High throughput screening (Drug development) |2 fast | |
| 700 | 1 | |a Dillon, Susan. | |
| 776 | 1 | |z 9780123693938 | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=282102 |z Texto completo |
| 938 | |a 123Library |b 123L |n 44592 | ||
| 938 | |a ProQuest MyiLibrary Digital eBook Collection |b IDEB |n 70760 | ||
| 938 | |a YBP Library Services |b YANK |n 2585775 | ||
| 994 | |a 92 |b IZTAP | ||