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Biomedical informatics in translational research /
This groundbreaking resource on biomedical informatics gives you step-by-step insight into innovative techniques for integrating and federating data from clinical and high-throughput molecular study platforms as well as from the public domain. It details how to apply computational and statistical te...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Boston :
Artech House,
©2008.
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| Colección: | Artech House bioinformatics & biomedical imaging series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Biomedical Informatics in Translational Research; Contents; Preface; Chapter 1 Biomedical Informatics in TranslationalResearch; 1.1 Evolution of Terminology; 1.1.1 Translational Research; 1.1.2 Systems Biology; 1.1.3 Personalized Medicine; References; Chapter 2 The Clinical Perspective; 2.1 Introduction; 2.2 Ethics in Clinical Research; 2.3 Regulatory Policies for Protecting a Research Subject's Privacy; 2.4 Informed Consent; 2.5 Collecting Clinical Data: Developing and Administering Survey Instruments; 2.6 Issues Important to Biomedical Informatics; 2.6.1 Data Tracking and Centralization.
- 2.6.2 Deidentifying Data2.6.3 Quality Assurance; 2.6.4 Data Transfer from the Health Care Clinic to the Research Setting; 2.7 Standard Operating Procedures; 2.8 Developing and Implementing a Research Protocol; 2.8.1 Developing a Research Protocol; 2.8.2 Implementing the Research Protocol; 2.9 Summary; References; Chapter 3 Tissue Banking: Collection, Processing, and Pathologic Characterization of Biospecimens for Research; 3.1 Introduction; 3.1.1 A Biorepository's Mandate; 3.1.2 Overview of Current Tissue Banking Practices; 3.2 Consenting and Clinical Data Acquisition.
- 3.3 Blood Collection, Processing, and Storage3.4 Tissue Collection, Processing, Archiving, and Annotation; 3.4.1 Tissue Collection; 3.4.2 Tissue Processing; 3.4.3 Tissue Archiving and Storage; 3.4.4 Pathologic Characterization of Tissue Samples; 3.5 Conclusion; References; Chapter 4 Biological Perspective; 4.1 Background for "Omics" Technologies; 4.2 Basic Biology and Definitions; 4.2.1 A Historical Perspective; 4.2.2 Biological Processes; 4.2.3 Some Definitions; 4.3 Very Basic Biochemistry; 4.3.1 DNA; 4.3.2 RNA; 4.3.3 Proteins; 4.4 Summary; References; Chapter 5 Genomics Studies.
- 5.1 Introduction5.2 Genomic Technologies Used for DNA Analysis; 5.2.1 DNA Sequencing; 5.2.1.2 Biomedical Informatics Requirements; 5.2.1.3 Future Directions; 5.2.2 Genotyping; 5.2.2.1 Array Technologies; 5.2.2.2 Technological Assessment of Genotyping; 5.2.2.3 Affymetrix Genotyping SNP Assay Workflow; 5.2.2.4 QA/SOP Issues; 5.2.2.5 Biomedical Informatics Requirements; 5.2.2.6 Future Directions; 5.2.3 Array-Based Comparative Genomic Hybridization; 5.2.3.1 Technological Assessment of Chromosomal Rearrangements; 5.2.3.2 Example Platform; 5.2.3.3 QA/SOP Issues.
- 5.2.3.4 Biomedical Informatics Requirements5.2.3.5 Oligo-Based aCGH Platform; 5.3 Genomic Technology Used for RNA Analysis; 5.3.1 Real-Time PCR; 5.3.1.1 Data Analysis Methods; 5.3.1.2 Biomedical Informatics Requirements; 5.3.1.3 Future Directions; 5.3.2 Microarrays; 5.3.2.1 Array Technologies; 5.3.2.2 Example Platform; 5.3.2.3 QA/SOP Issues; 5.3.2.4 MIAME Checklist and Platform Comparison; 5.3.2.5 Data Analysis Issues; 5.3.2.6 Biomedical Informatics Requirements; 5.3.2.7 Future Directions; 5.3.3 Chips for Alternative Splicing Analysis (GeneChip Exon); 5.3.3.1 Array Technology.