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Pathophysiology of nonalcoholic steatohepatitis /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Basaranoglu, Metin
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Biomedical Books, ©2009.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • PATHOPHYSIOLOGY OFNONALCOHOLICSTEATOHEPATITIS
  • NOTICE TO THE READER
  • CONTENTS
  • PREFACE
  • ABBREVIATIONS
  • PATHOPHYSIOLOGY OF EXCESSIVE FATACCUMULATION IN THE LIVER IN THEABSENCE OF ALCOHOL ABUSE: NAFLD
  • OBESITY, INSULIN RESISTANCE ANDHYPERINSULINEMIA AS RISK FACTORS FOR NAFLD
  • SOURCES OF LIVER FAT
  • Dysregulated Peripheral Lipolysis
  • Hepatic de Novo Lipogenesis (DNL)
  • Uptake of Dietary Fat into the Liver
  • FATES OF LIVER FAT
  • Very-low-density Lipoprotein (VLDL) Synthesis and Secretion
  • Mitochondrial β-Oxidation
  • Peroxisomal Fatty Acid β-OxidationCytochrome P450 Fatty Acid Ï? (Omega)-Oxidation
  • Local and Generalized Inflammation in NAFLD
  • NASH: THE PATHOGENESIS OFHEPATOCELLULAR INJURY IN NAFLD
  • ROLE OF ANIMAL MODELS IN UNDERSTANDING THEPATHOGENESIS OF NASH
  • The ob/ob Mouse
  • The Methionine and Choline Deficient (MCD) Diet
  • Other Dietary Models
  • Transition from Simple Steatosis and NASH to NASH-AssociatedHCC: A new Murine NASH-Associated Hepatic Neoplasia Mo
  • OXIDATIVE STRESS AND THE PATHOGENESIS OFNASH
  • Mitochondria as a Source of Oxidant Stress
  • P450 as a Source of Oxidant StressIron, Oxidant Stress and NASH
  • MITOCHONDRIAL DYSFUNCTION AND ATPDEPLETION
  • FREE FATTY ACID TOXICITY
  • ENDOGENOUS TOXINS:ENDOTOXIN AND GUT-DERIVED ETHANOL
  • ADIPOCYTOKINES
  • Leptin
  • Adiponectin
  • TNF-Î"
  • IL-6
  • Resistin
  • Regulation of Hepatic Immunity and Increased Sensitivity toHepatocellular Injury
  • HEPATOCYTE APOPTOSIS IN NAFLD
  • HEPATIC FIBROGENESIS IN NASH
  • ROLE OF STELLATE CELLS AND CYTOKINES INHEPATIC FIBROGENESIS
  • HEPATOCELLULAR CARCI
  • PATHOPHYSIOLOGY OF THEPATHOLOGICAL FEATURES OF NASH
  • MICROVESICULAR AND MACROVESICULAR STEATOSISINFLAMMATION
  • GLYCOGEN NUCLEI
  • LIPOGRANULOMAS
  • HEPATOCELLULAR BALLOONI
  • HEPATOCELLULAR BALLOONING
  • MALLORY BODIES AND STRESS PROTEINS
  • GENETIC SUSCEPTIBILITY TO NASH AND THE BASISOF NASH-PATHOPHYSIOLOGY
  • NASH Prevalence in Different Racial and Ethnic Groups
  • NAFLD and Genes Associated with Lipid and Glucose Metabolism, Oxidant and Anti-Oxidant Systems, and ProinflammatoryCytokines
  • SUMMARY
  • REFERENCES
  • INDEX