Integrated cardiac safety : assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance /

Mostrar otras versiones (1)

The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and methodology for professionals ass...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Turner, J. Rick
Otros Autores: Durham, Todd A.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : John Wiley & Sons, ©2009.
Temas:
Cardiovascular toxicology.
Heart > Effect of drugs on.
Drugs > Side effects > Testing.
Drugs > Safety measures.
Drugs > Design.
Medication errors.
Cardiovascular Diseases > prevention & control
Drug Design
Medication Errors
Product Surveillance, Postmarketing > methods
Safety Management > methods
Toxicologie cardiovasculaire.
Cœur > Effets des médicaments sur.
Médicaments > Sécurité > Mesures.
Médicaments > Conception.
Erreurs de médication.
HEALTH & FITNESS > Diseases > Heart.
MEDICAL > Cardiology.
Medication errors
Drugs > Design
Cardiovascular toxicology
Drugs > Safety measures
Heart > Effect of drugs on
Acceso en línea:Texto completo
Tabla de Contenidos:
  • The importance of cardiac safety assessments
  • The biological basis of adverse drug reactions
  • Cardiac structure and function
  • Cardiac pathophysiology and disease
  • Drug discovery and drug design
  • Nonclinical development
  • The thorough QT/QTc trial
  • General safety assessments
  • Therapeutic use trials and meta-analyses
  • Assessment methodologies in nonexperimental postmarketing surveillance
  • Postmarketing proarrhythmic cardiac safety assessments
  • Generalized cardiac safety
  • Medication errors, adherence, and concordance
  • Future directions in drug safety.

Ejemplares similares