Process scale purification of antibodies /

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Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling beco...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Gottschalk, Uwe
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : John Wiley & Sons, ©2009.
Temas:
Monoclonal antibodies > Purification.
Biochemical engineering.
Antibodies, Monoclonal > isolation & purification
Antibodies, Monoclonal > therapeutic use
Chromatography > methods
Technology, Pharmaceutical > methods
Génie biochimique.
MEDICAL > Drug Guides.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
MEDICAL > Nursing > Pharmacology.
Biochemical engineering
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Downstream processing of monclonal antibodies: current practices and future opportunities / Brian Kelley, Greg Blank, and Ann Lee
  • The development of antibody purification technologies / John Curling
  • Harvest and recovery of monoclonal antibodies: cell removal and clarification / Abhinav A. Shukla and Jagannadha Rao Kandula
  • Protein A-based affinity chromatography / Suresh Vunnum, Ganesh Vedantham, and Brian Hubbard
  • Purification of human monoclonal antibodies: non-protein A strategies / Alahari Arunakumari and Jue Wang
  • Purification of monoclonal antibodies by mixed-mode chromatography / Pete Gagnon
  • Integrated polishing steps for monoclonal antibody purification / Sanchayita Ghose [and others]
  • Orthogonal virus clearance applications in monoclonal antibody production / Joe X. Zhou
  • Development of a platform process for the purification of therapeutic monoclonal antibodies / Yuling Li [and others]
  • Advances in technology and process development for industrial-scale monoclonal antibody purification / Nuno Fontes and Robert van Reis
  • Continuous chromatography for the purification of monclonal antibodies / Thomas Muller-Spath and Massimo Morbidelli
  • Process economic drivers in industrial monoclonal antibody manufacture / Suzanne S. Farid
  • Design and optimization of manufacturing / Andrew Sinclair
  • Alternatives to packed-bed chromatography for antibody extraction and purification / Jörg Thömmes and Uwe Gottschalk
  • Process-scale precipitation of impurities in mammalian cell culture broth / Judy Glynn
  • Charged ultrafiltration and microfiltration membranes in antibody purification / Mark R. Etzel
  • Downstream processing of monoclonal antibody fragments / Mariangela Spitali
  • Purification of antibodies other than IgG: the case of IgM and IgA / Charlotte Cabanne and Xavier Santarelli
  • Purification of antibodies from transgenic plants / Zivko L. Nikolov [and others]
  • Antibody purification: drivers of change / Narahari Pujar, Duncan Low, and Rhona O'Leary.

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