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Process scale purification of antibodies /

Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling beco...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Gottschalk, Uwe
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : John Wiley & Sons, ©2009.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Process scale purification of antibodies /  |c edited by Uwe Gottschalk. 
260 |a Hoboken, N.J. :  |b John Wiley & Sons,  |c ©2009. 
300 |a 1 online resource (xxvi, 430 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
500 |a Errata slip inserted. 
504 |a Includes bibliographical references and index. 
588 0 |a Print version record. 
520 |a Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to addres. 
505 0 |a Downstream processing of monclonal antibodies: current practices and future opportunities / Brian Kelley, Greg Blank, and Ann Lee -- The development of antibody purification technologies / John Curling -- Harvest and recovery of monoclonal antibodies: cell removal and clarification / Abhinav A. Shukla and Jagannadha Rao Kandula -- Protein A-based affinity chromatography / Suresh Vunnum, Ganesh Vedantham, and Brian Hubbard -- Purification of human monoclonal antibodies: non-protein A strategies / Alahari Arunakumari and Jue Wang -- Purification of monoclonal antibodies by mixed-mode chromatography / Pete Gagnon -- Integrated polishing steps for monoclonal antibody purification / Sanchayita Ghose [and others] -- Orthogonal virus clearance applications in monoclonal antibody production / Joe X. Zhou -- Development of a platform process for the purification of therapeutic monoclonal antibodies / Yuling Li [and others] -- Advances in technology and process development for industrial-scale monoclonal antibody purification / Nuno Fontes and Robert van Reis -- Continuous chromatography for the purification of monclonal antibodies / Thomas Muller-Spath and Massimo Morbidelli -- Process economic drivers in industrial monoclonal antibody manufacture / Suzanne S. Farid -- Design and optimization of manufacturing / Andrew Sinclair -- Alternatives to packed-bed chromatography for antibody extraction and purification / Jörg Thömmes and Uwe Gottschalk -- Process-scale precipitation of impurities in mammalian cell culture broth / Judy Glynn -- Charged ultrafiltration and microfiltration membranes in antibody purification / Mark R. Etzel -- Downstream processing of monoclonal antibody fragments / Mariangela Spitali -- Purification of antibodies other than IgG: the case of IgM and IgA / Charlotte Cabanne and Xavier Santarelli -- Purification of antibodies from transgenic plants / Zivko L. Nikolov [and others] -- Antibody purification: drivers of change / Narahari Pujar, Duncan Low, and Rhona O'Leary. 
590 |a ProQuest Ebook Central  |b Ebook Central Academic Complete 
650 0 |a Monoclonal antibodies  |x Purification. 
650 0 |a Biochemical engineering. 
650 1 2 |a Antibodies, Monoclonal  |x isolation & purification 
650 2 2 |a Antibodies, Monoclonal  |x therapeutic use 
650 2 2 |a Chromatography  |x methods 
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700 1 |a Gottschalk, Uwe. 
758 |i has work:  |a Process scale purification of antibodies (Text)  |1 https://id.oclc.org/worldcat/entity/E39PCFGvmhJtjKMJd9MwG3Dqry  |4 https://id.oclc.org/worldcat/ontology/hasWork 
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