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The cancer degradome : proteases and cancer biology /
This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer,
©2008.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- The Degradome and Its Analysis
- Protease Genomics and the Cancer Degradome
- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes
- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment
- Quantitative Real-Time PCR Analysis of Degradome Gene Expression
- Identification of Protease Substrates by Mass Spectrometry Approaches-1
- Identification of Protease Substrates by Mass Spectrometry Approaches-2
- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome
- Images of Cleavage: Tumor Proteases in Action
- Insights into Protease Function
- Proteolytic Pathways: Intersecting Cascades in Cancer Development
- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice
- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion
- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy
- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling
- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations
- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models
- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions
- The Surface Transplantation Model to Study the Tumor-Host Interface
- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo
- New Insights into MMP function in Adipogenesis
- TIMPs: Extracellular Modifiers in Cancer Development
- The Interface Between Proteolysis and Cell Signalling
- Invadopodia: Interface for Invasion
- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells
- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome
- Measuring uPAR Dynamics in Live Cells
- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis
- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules
- Matrix Metalloproteinases as Key Regulators of Tumor-Bone Interaction
- The Degradome as Source of Cancer Diagnostic and Markers
- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer
- Cysteine Cathepsins and Cystatins as Cancer Biomarkers
- Novel Degradome Markers in Breast Cancer
- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues
- Degradome Gene Polymorphisms
- TIMP-1 as a Prognostic Marker in Colorectal Cancer
- Novel Therapeutic Strategies
- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor
- Engineered Antagonists of uPA and PAI-1
- MMP Inhibitor Clinical Trials
- The Past, Present, and Future
- Tailoring TIMPs for Selective Metalloproteinase Inhibition
- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors
- Protease-Activated Delivery and Imaging Systems
- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics
- Targeting Degradome Genes via Engineered Viral Vectors.