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The cancer degradome : proteases and cancer biology /
This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer,
©2008.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 024 | 7 | |a 10.1007/978-0-387-69057-5. |2 doi | |
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| 037 | |a 978-0-387-69056-8 |b Springer |n http://www.springerlink.com | ||
| 050 | 4 | |a QP609.P78 |b C36 2008eb | |
| 060 | 4 | |a QU 136 |b C215 2008 | |
| 072 | 7 | |a SCI |x 007000 |2 bisacsh | |
| 072 | 7 | |a MJCL. |2 bicssc | |
| 082 | 0 | 4 | |a 572/.76 |2 22 |
| 084 | |a R730. 231 |2 clc | ||
| 049 | |a UAMI | ||
| 245 | 0 | 4 | |a The cancer degradome : |b proteases and cancer biology / |c Dylan Edwards [and others], editors. |
| 246 | 3 | 0 | |a Proteases and cancer biology |
| 260 | |a New York, NY : |b Springer, |c ©2008. | ||
| 300 | |a 1 online resource (xxiii, 926 pages, 32 unnumbered pages of plates) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a data file | ||
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both in vitro and in vivo; the links that have emerged between proteolysis and cell signalling; how the degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to targeting proteolysis for therapy. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a The Degradome and Its Analysis -- Protease Genomics and the Cancer Degradome -- The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes -- The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment -- Quantitative Real-Time PCR Analysis of Degradome Gene Expression -- Identification of Protease Substrates by Mass Spectrometry Approaches-1 -- Identification of Protease Substrates by Mass Spectrometry Approaches-2 -- Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome -- Images of Cleavage: Tumor Proteases in Action -- Insights into Protease Function -- Proteolytic Pathways: Intersecting Cascades in Cancer Development -- Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice -- The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion -- The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy -- The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling -- Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations -- Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models -- In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions -- The Surface Transplantation Model to Study the Tumor-Host Interface -- Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo -- New Insights into MMP function in Adipogenesis -- TIMPs: Extracellular Modifiers in Cancer Development -- The Interface Between Proteolysis and Cell Signalling -- Invadopodia: Interface for Invasion -- uPAR and Proteases in Mobilization of Hematopoietic Stem Cells -- The Urokinase Receptor and Integrins Constitute a Cell Migration Signalosome -- Measuring uPAR Dynamics in Live Cells -- Janus-Faced Effects of Broad-Spectrum and Specific MMP Inhibition on Metastasis -- Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules -- Matrix Metalloproteinases as Key Regulators of Tumor-Bone Interaction -- The Degradome as Source of Cancer Diagnostic and Markers -- The Plasminogen Activation System as a Source of Prognostic Markers in Cancer -- Cysteine Cathepsins and Cystatins as Cancer Biomarkers -- Novel Degradome Markers in Breast Cancer -- Meta-Analysis of Gene Expression Microarray Data: Degradome Genes in Healthy and Cancer Tissues -- Degradome Gene Polymorphisms -- TIMP-1 as a Prognostic Marker in Colorectal Cancer -- Novel Therapeutic Strategies -- Structure and Inhibition of the Urokinase-Type Plasminogen Activator Receptor -- Engineered Antagonists of uPA and PAI-1 -- MMP Inhibitor Clinical Trials -- The Past, Present, and Future -- Tailoring TIMPs for Selective Metalloproteinase Inhibition -- Third-Generation MMP Inhibitors: Recent Advances in the Development of Highly Selective Inhibitors -- Protease-Activated Delivery and Imaging Systems -- Development of Tumour-Selective and Endoprotease-Activated Anticancer Therapeutics -- Targeting Degradome Genes via Engineered Viral Vectors. | |
| 546 | |a English. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Proteolytic enzymes. | |
| 650 | 0 | |a Cancer |x Molecular aspects. | |
| 650 | 1 | 2 | |a Peptide Hydrolases |
| 650 | 2 | 2 | |a Neoplasm Invasiveness |x enzymology |
| 650 | 6 | |a Enzymes protéolytiques. | |
| 650 | 6 | |a Cancer |x Aspect moléculaire. | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 0 | 7 | |a Cancer |x Molecular aspects. |2 cct |
| 650 | 0 | 7 | |a Peptide hydrolases. |2 cct |
| 650 | 0 | 7 | |a Neoplasm Invasiveness |x enzymology. |2 cct |
| 650 | 0 | 7 | |a Proteolytic enzymes. |2 cct |
| 650 | 7 | |a Biomédecine. |2 eclas | |
| 650 | 7 | |a Sciences de la vie. |2 eclas | |
| 650 | 7 | |a Cancer |x Molecular aspects |2 fast | |
| 650 | 7 | |a Proteolytic enzymes |2 fast | |
| 700 | 1 | |a Edwards, Dylan R. | |
| 758 | |i has work: |a The cancer degradome (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGDm4fmmX67XvjqxMRJyHP |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |t Cancer degradome. |d New York, NY : Springer, ©2008 |z 9780387690568 |z 0387690565 |w (OCoLC)227032670 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=364191 |z Texto completo |
| 938 | |a Coutts Information Services |b COUT |n 9044205 | ||
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