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Galectins /

This is the first book specifically on galectins?a challenging and promising area in medical biochemistry and drug design. After an introduction to galectins, the book covers their structure and functions, ligand specificity, and molecular mechanisms of action, along with the roles galectins play in...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Klesov, A. A. (Anatoliĭ Alekseevich), Witczak, Zbigniew J., 1947-, Platt, David, 1953-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : Wiley, ©2008.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Galectins /  |c edited by Anatole A. Klyosov, Zbigniew J. Witczak, David Platt. 
260 |a Hoboken, N.J. :  |b Wiley,  |c ©2008. 
300 |a 1 online resource (xi, 279 pages, 8 unnumbered pages of plates) :  |b illustrations (some color) 
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504 |a Includes bibliographical references and index. 
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505 0 |a GALECTINS; CONTENTS; Preface; Contributors; 1 Stumbling on Galectins; 2 Galectins and Their Functions in Plain Language; 3 Understanding Galectin Structure-Function Relationships to Design Effective Antagonists; 4 Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design; 5 Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and Their Roles in Pre-mRNA Splicing; 6 Galectins in Regulation of Inflammation and Immunity. 
505 8 |a 7 Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins"?8 The Role of Galectins in Organ Fibrosis; 9 Galectin-1, Cancer Cell Migration, Angiogenesis, and Chemoresistance; 10 Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia; 11 Galectins in Malignant Gliomas: Expression, Functions, and Possible Therapeutic Options; 12 Food-Related Carbohydrate Ligands for Galectins; Index. 
520 |a This is the first book specifically on galectins?a challenging and promising area in medical biochemistry and drug design. After an introduction to galectins, the book covers their structure and functions, ligand specificity, and molecular mechanisms of action, along with the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity. Then it covers the effect of galectins on cell migration, angiogenesis, and chemoresistance and describes new approaches to designing galectin inhibitors. This is a core reference for chemists, biochemists, pharmacologists, biologists. 
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650 0 |a Galactose. 
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650 2 |a Lectins 
650 2 |a Galactose 
650 2 2 |a Galectins  |x metabolism 
650 2 2 |a Galectins  |x pharmacology 
650 6 |a Lectines. 
650 6 |a Galactose. 
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650 7 |a Lectins  |2 fast 
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700 1 |a Witczak, Zbigniew J.,  |d 1947-  |1 https://id.oclc.org/worldcat/entity/E39PBJjT4K3vTk7DBJfrj4RtKd 
700 1 |a Platt, David,  |d 1953-  |1 https://id.oclc.org/worldcat/entity/E39PCjKXkdQRT8rbJV4r9b7Hvd 
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