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|a 978-3-540-75156-4
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|a RNA interference /
|c Patrick J. Paddison, Peter K. Vogt, editors.
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|a Ribonucleic acid interference
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|a Berlin :
|b Springer,
|c ©2008.
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|a 1 online resource (viii, 273 pages) :
|b illustrations (some color)
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|a Current topics in microbiology and immunology ;
|v v. 320
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|a Includes bibliographical references and index.
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|a RNA interference in mammalian cell systems / Patrick J. Paddison -- RNAi pathway in C. elegans: the argonautes and collaborators / Marie-Eve L. Boisvert and Martin J. Simard -- Genetics and biochemistry of RNAi in drosophila / Harsh H. Kavi [and others] -- Role of dicer in posttranscriptional RNA silencing / Lukasz Jaskiewicz and Witold Filipowicz -- The mechanism of RNase III action: how dicer dices / Xinhua Ji -- MicroRNA metabolism in plants / Xuemei Chen -- Structure-function relationships among RNA-dependent RNA polymerases / Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron -- RNAi-mediated chromatin silencing in fission yeast / Sharon A. White and Robin C. Allshire -- A role for RNAi in heterochromatin formation in drosophila / Nicole C. Riddle and Sarah C.R. Elgin -- RNA mediated transcriptional gene silencing in human cells / Kevin V. Morris -- RNA silencing in mammalian oocytes and early embryos / Petr Svoboda -- Identifying human microRNAs / Isaac Bentwich.
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|a In the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems for the first time in academia and industry. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.
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|a Print version record.
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546 |
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|a English.
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506 |
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|a University staff and students only. Requires University Computer Account login off-campus.
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590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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650 |
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|a RNA.
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|a Gene silencing.
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|a RNA interference.
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|a Small interfering RNA.
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|a MicroRNA.
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|a RNA Interference
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|a RNA, Small Interfering
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|a Gene Silencing
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|a RNA
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|a Microbiology
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|a Petits ARN interférents.
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|a Microbiologie.
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|a microbiology.
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|2 bisacsh
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|a RNA, Small Interfering.
|2 cct
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|a Gene silencing.
|2 cct
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|a MicroRNAs.
|2 cct
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|a RNA.
|2 cct
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|a RNA Interference.
|2 cct
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|a Biomédecine.
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|a Small interfering RNA
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|a RNA interference
|2 fast
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|2 fast
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|a Gene silencing
|2 fast
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|2 fast
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1 |
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|a Paddison, Patrick J.
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700 |
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|a Vogt, P. K.
|q (Peter K.),
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|1 https://id.oclc.org/worldcat/entity/E39PBJjCPhJKVkxRpRt3PPDjG3
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758 |
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|i has work:
|a RNA interference (Text)
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|a Current topics in microbiology and immunology ;
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