Alternatives to animal testing /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Hester, R. E. (Ronald E.), Harrison, Roy M., 1948-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge : Royal Society of Chemistry, ©2006.
Colección:Issues in environmental science and technology ; 23.
Temas:
Alternative toxicity testing.
Animal experimentation.
Animal Testing Alternatives
Animal Experimentation
Expérimentation animale > Alternative.
Expérimentation animale.
Chemistry.
MEDICAL > Toxicology.
Science.
Alternative toxicity testing
Animal experimentation
Medical laboratory testing & techniques.
Environmental science, engineering & technology.
Medical ethics & professional conduct.
Health and Wellbeing.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • GENERAL OVERVIEW OF THE SAFETY EVALUATION OF CHEMICALS / Paul Illing
  • Introduction
  • Legislation and regulatory requirements
  • The regulatory paradigm
  • The interface between toxicology and risk assessment
  • Interpreting toxicology
  • Conclusions
  • References
  • INTERNATIONAL VALIDATION AND BARRIERS TO THE VALIDATION OF ALTERNATIVE TESTS / Michael Balls
  • Introduction
  • Background to the validation process
  • The validation process
  • Problems being encountered in implementing the validation process
  • The need for an invalidation process
  • Concluding remarks
  • References
  • IN VITRO TESTING FOR ENDOCRINE DISRUPTORS / Robert D. Combes
  • Introduction
  • In silico approaches
  • In vitro tests for EDs
  • Discussion
  • Conclusions
  • Acknowledgment
  • References
  • iNTELLIGENT APPROACHES TO SAFETY EVALUATION / Derek J. Knight
  • Introduction
  • Hazardous properties assessment
  • Risk assessment
  • Existing studies and literature data
  • Surrogate data: calculation, read across and SAR/QSAR
  • Alternatives to animal toxicology studies
  • Data waivers
  • Expert reports and weight of evidence
  • Preliminary risk assessments
  • EU Registration, Evaluation and Registration Scheme (REACH)
  • Data for REACH
  • Regulatory planning & liaison with the regulators
  • Common themes
  • Acknowledgments
  • References
  • ALTERNATIVE TESTS AND THE 7TH AMENDMENT TO THE COSMETICS DIRECTIVE / Carl Westmoreland
  • Introduction
  • Overview of current approaches to risk assessment for cosmetics
  • 7th Amendment to the EU Cosmetics Directive (76/768/EEC)
  • Status of alternative tests
  • Endpoints where risk assessment for cosmetics can be achieved without using animal data
  • Endpoints where risk assessment for cosmetics cannot currently be achieved without using animal data
  • New approaches to risk assessment without animals
  • Acknowledgments
  • Abbreviations
  • References.

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