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Preclinical development handbook. ADME and biopharmaceutical properties /
This book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process and a compendium of methods and techniques that need to.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
Wiley-Interscience,
©2008.
|
| Colección: | Pharmaceutical Development Series.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Preclinical development handbook. |p ADME and biopharmaceutical properties / |c [edited by] Shayne Cox Gad. |
| 246 | 3 | 0 | |a ADME and biopharmaceutical properties |
| 260 | |a Hoboken, N.J. : |b Wiley-Interscience, |c ©2008. | ||
| 300 | |a 1 online resource (xv, 1329 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Pharmaceutical Development Series | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a This book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process and a compendium of methods and techniques that need to. | ||
| 505 | 0 | |a PRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration | |
| 505 | 8 | |a 10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions | |
| 505 | 8 | |a 23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies | |
| 505 | 8 | |a 33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; Index | |
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| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Computer simulation. | |
| 650 | 0 | |a Digital computer simulation. | |
| 650 | 0 | |a Chemical models. | |
| 650 | 1 | 2 | |a Drug Design |
| 650 | 2 | 2 | |a Computational Biology |x methods |
| 650 | 2 | 2 | |a Computer Simulation |
| 650 | 2 | 2 | |a Models, Chemical |
| 650 | 2 | 2 | |a Pharmaceutical Preparations |x metabolism |
| 650 | 6 | |a Pharmacocinétique |v Guides, manuels, etc. | |
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| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Pharmacokinetics |2 fast | |
| 655 | 2 | |a Handbook | |
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| 700 | 1 | |a Gad, Shayne C., |d 1948- |1 https://id.oclc.org/worldcat/entity/E39PBJtMv3dQXtdXFvrKPThPwC | |
| 758 | |i has work: |a Preclinical development handbook ADME and biopharmaceutical properties (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGGVMgcPMHRFthGg7py7h3 |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |t Preclinical development handbook. ADME and biopharmaceutical properties. |d Hoboken, N.J. : Wiley-Interscience, ©2008 |z 9780470248478 |z 0470248475 |w (DLC) 2008003750 |w (OCoLC)176895587 |
| 830 | 0 | |a Pharmaceutical Development Series. | |
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