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Diabetes mellitus : a fundamental and clinical text /

Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: LeRoith, Derek, 1945-, Taylor, Simeon I., Olefsky, Jerrold M.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Philadelphia : Lippincott Williams & Wilkins, ©2004.
©2004
Edición:3rd ed.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. The Two Phases of Glucose-Stimulated Insulin Secretion: Mechanisms and Controls / Susanne G. Straub and Geoffrey W.G. Sharp
  • 2. Insulin Gene Regulation / Michael German
  • 3. Processing of the Insulin Molecule / Christopher J. Rhodes
  • 4. Electrophysiology of the Pancreatic [beta]-Cell / Khaled Houamed, Jian Fu, Michael William Roe and Louis H. Philipson
  • 5. Sulfonylurea Receptors, Andenosine Triphosphate-Sensitive Potassium Channels, and Insulin Secretion / Joseph Bryan and Lydia Aguilar-Bryan
  • 6. Insulinotropic Glucagon-Like Peptides / Joel F. Habener and Daniel M. Kemp
  • 7. Detrimental Effects of Chronic Hyperglycemia on the Pancreatic [beta]-Cell / Jack L. Leahy
  • 8. Glucose Toxicity of the [beta]-Cell: Cellular and Molecular Mechanisms / P. Paul Robertson, Jamie Harmon, Yoshito Tanaka, Phuong Oanh Tran and Vincent Poitout
  • 9. Lipotoxity / Roger H. Unger
  • 10. Islet Amyloid in Type 2 Diabetes / Rebecca L. Hull and Steven E. Kahn
  • 11. Physiologic Action of Insulin / Paul J. Flakoll, Michael D. Jensen and Alan D. Cherrington
  • 12. Integration of Biochemical and Physiologic Effects of Insulin on the Control of Blood Glucose Concentrations / George Dimitriadis and Eric A. Newsholme
  • 13. Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia / Philip E. Cryer
  • 14. The Role of Insulin Receptor Substrate Proteins in Insulin Signaling and Metabolic Regulation / Liangyou Rui and Morris F. White
  • 15. The Insulin Signaling Network and Insulin Action / Yehiel Zick
  • 16. Knockout Mice as a Tool to the Understanding of Diabetes Mellitus / Katrine Almind, Domenico Accili and C. Ronald Kahn
  • 17. Regulation of Insulin Action by Protein-Tyrosine Phosphatases / Barry J. Goldstein
  • 18. Small GTPases and Serine/Threonine Protein Kinase Cascades in Insulin Signal Transduction / Joseph Avruch
  • 19. Protein Kinase C / Robert V. Farese
  • 20. Regulation of Glycogen Synthesis / Alexander V. Skurat and Peter J. Roach
  • 21. Insulin Action on Glucose Transport / Michael P. Czech, James L. Erwin and Mark W. Sleeman
  • 22. Cellular and Molecular Processes Regulating Glucose Transporter 4 Translocation / June Chunqiu Hou, Alan R. Saltiel and Jeffrey E. Pessin
  • 23. Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes / Constantine Londos
  • 24. Role for Phosphodiesterase 3B in Regulation of Lipolysis and Insulin Secretion / Eva Degerman, Tova Rahn Landstrom, Lena Stenson Holst, Olga Goransson, Linda Harndahl, Faiyaz Ahmad, Young-Hun Choi, Silvia Masciarelli, Hanguan Liu and Vincent Manganiello
  • 25. Gene Regulation / Richard M. O'Brien and Daryl K. Granner
  • 26. Insulin Degradation / Richard A. Roth, Li Ding and Andrew Becker
  • 27. Insulin and the Ras-Dependent Signaling Pathway / Marc L. Goalstone and Boris Draznin
  • 28. Germline Manipulation of Glucose Transport and Glucose Homeostasis / Mike Mueckler
  • 29. Molecular Links between Peroxisome Proliferator-Activated Receptor-[gamma] and Metabolic Disease / Gregg W. Van Citters and Barry M. Forman
  • 30. Definition and Classification of Diabetes Mellitus and the Criteria for Diagnosis / Maureen I. Harris
  • 31. The Natural History of Autoimmunity in Type 1A Diabetes Mellitus / Jennifer M. Barker and George S. Eisenbarth
  • 32. Genetics of Type 1 Diabetes / Martin Hessner, Xujing Wang and Soumitra Ghosh
  • 33. Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus / Lisa K. Gilliam, Jerry P. Palmer and Ake Lernmark
  • 34. Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus / Alexander Rabinovitch
  • 35. Major Histocompatibility Locus and Other Genes That Determine the Risk for Development of Type 1 Diabetes Mellitus / Massimo Pietropaolo and Massimo Trucco
  • 36. Associations between Immune-Mediated (Type 1) Diabetes and Other Autoimmune Diseases / Svetlana Ten, Anjli Kukreja and Noel Maclaren
  • 37. Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus / Ji-Won Yoon and Hee-Sook Jun
  • 38. Animal Models of Autoimmune Diabetes Mellitus / John P. Mordes, David V. Serreze, Dale L. Greiner and Aldo A. Rossini
  • 39. Insights from Transgenic and Gene Targeting Strategies in Type 1 Diabetes / Thomas W.H. Kay and Leonard C. Harrison
  • 40. Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome / Elizabeth D. Ennis and Robert A. Kreisberg
  • 41. Application of the Diabetes Control and Complication Trial / Saul Genuth
  • 42. Diet Therapy in Type 1 Diabetes Mellitus / Christine Beebe
  • 43. Exercise for the Patient with Type 1 Diabetes Mellitus / Jeanne H. Steppel and Edward S. Horton
  • 44. Insulin Therapy and Home Monitoring for Type 1 Diabetes Mellitus / Stuart J. Brink
  • 45. Immune Intervention / Jay S. Skyler and Jennifer B. Marks
  • 46. Islet Cell Transplantation / Antonello Pileggi, Rodolfo Alejandro, Daniel H. Mintz, Camillo Ricordi and Norma S. Kenyon
  • 47. Islet Transplantation / Breay W. Paty, Edmond A. Ryan, Jonathan R.T. Lakey and A.M. James Shapiro
  • 48. Pancreas Transplantation / David E.R. Sutherland, Rainer W.G. Gruessner, S. Michael Mauer and Angelika C. Gruessner
  • 49. Gene Therapy for Metabolic Disease / Anthony T. Cheung and Timothy J. Kieffer
  • 50. Surrogate [beta]-cells for Insulin Replacement Therapy / Christopher B. Newgard and Shimon Efrat
  • 51. Stem Cells / Anandwardhan A. Hardikar and Marvin C. Gershengorn
  • 52. Epidemiology of Type 2 Diabetes Mellitus / Dana Dabelea and Richard F. Hamman
  • 53. Metabolic Abnormalities in the Development of Type 2 Diabetes Mellitus / P. Antonio Tataranni and Clifton Bogardus
  • 54. Noninvasive Imaging of Insulin Action and Resistance in Humans / David E. Kelley and Frederico G.S. Toledo
  • 55. Genetics of Human Obesity / Oluf Pedersen and Soren M. Echwald
  • 56. Obesity: Treatment / Xavier Pi-Sunyer
  • 57. Obesity in Type 2 Diabetes Mellitus / Henning Beck-Nielsen and Ole Hother-Nielsen
  • 58. Effects of Aging Glucose Homeostasis / Annette M. Chang and Jeffrey B. Halter
  • 59. Drug-Induced Diabetes Mellitus / Richard J. Comi
  • 60. Insulin Secretion in Type 2 Diabetes Mellitus / Gordon C. Weir and Susan Bonner-Weir
  • 61. Insulin Resistance and Its Consequences: Type 2 Diabetes Mellitus and the Insulin Resistance Syndrome / Gerald M. Reaven
  • 62. Glucose Transporters and Pathophysiologic States / E. Dale Abel, Peter R. Shepherd and Barbara B. Kahn
  • 63. Glucose Toxicity: Effect of Chronic Hyperglycemia on Insulin Action / Luciano Rossetti
  • 64. Inflammation, Tumor Necrosis Factor-[alpha], and Insulin Resistance / Gokhan S. Hotamisligil
  • 65. Adipokines: Regulators of Metabolic Integration and Energy Metabolism / Tsu-Shuen Tsao, Christopher Hug and Harvey F. Lodish
  • 66. Fatty Acids and Insulin Resistance / Guenther Boden
  • 67. Triglyceride in Muscle / Daniel T. Stein
  • 68. Candidate Genes for Type 2 Diabetes Mellitus / Mona M. Sabra, Alan R. Shuldiner and Kristi D. Silver
  • 69. Genetic Syndromes Associated with Severe Insulin Resistance: Mutations in the Insulin Receptor Gene and Lipotrophic Diabetes / Simeon I. Taylor, Elif Arioglu Oral and Domenico Accili
  • 70. Maturity-Onset Diabetes of the Young: A Model for Genetic Studies of Diabetes Mellitus / Stefan S. Fajans and Graeme I. Bell
  • 71. Rodent Genetic Models of Obesity and Type 2 Diabetes Mellitus / Marc L. Reitman
  • 72. Primate Animal Models of Type 2 Diabetes / Barbara C. Hansen
  • 73. Preventing Type 2 Diabetes: The Diabetes Prevention Program / David M. Nathan, Richard F. Hamman, Sanford Garfield, Anne Brenneman, Sarah F. Fowler and William C. Knowler
  • 74. Dietary Therapy in Type 2 Diabetes Mellitus: Spreading the Nutrient Load / David J.A. Jenkins, Alexandra L. Jenkins, Livia S.A.
  • 75. Exercise in Patients with Type 2 Diabetes Mellitus / Jeanne H. Steppel and Edward S. Horton
  • 76. Insulin Secretogogues: Sulfonylureas, Meglitinides, and Phenylalanine Derivatives / Harold E. Lebovitz
  • 77. Metformin / Alan J. Garber
  • 78. Peroxisome Proliferator-Activated Receptor Modulators / Garret J. Etgen, Melvin J. Prince and Jose F. Caro
  • 79. [alpha]-Glucosidase Inhibitors in the Treatment of Diabetes / Markus Rupp
  • 80. Glinides / James E. Foley and Lajwanti S. Khemlani
  • 81. Combination Therapy in Type 2 Diabetes Mellitus / Stanley H. Hsia and Mayer B. Davidson
  • 82. Intensive Insulin Therapy for Patients with Type 2 Diabetes / Sunder Mudaliar and Steven V. Edelman
  • 83. Hypoglycemia in Type 2 Diabetes Mellitus / Mark R. Burge, Aruna Chelliah and David S. Schade
  • 84. New Therapies to Promote Insulin Action / Guoqiang Jiang, Bei B. Zhang and David E. Moller
  • 85. Intermediary Metabolism during Pregnancy: Implications for Diabetes Mellitus / Thomas A. Buchanan
  • 86. Effects of Maternal Diabetes Mellitus on Intrauterine Development / Thomas A. Buchanan
  • 87. Pregnancy and Complications of Diabetes Mellitus: Maternal and Fetal Implications / Barak M. Rosenn and Menachem Miodovnik
  • 88. Gestational Diabetes Mellitus / Robert E. Ratner and Maureen D. Passaro
  • 89. Pathophysiology of Diabetic Retinopathy / Emily Y. Chew
  • 90. Pathogenesis of Diabetic Nephropathy / Gabriella Gruden, Luigi Gnudi and GianCarlo Viberti
  • 91. Diabetic Neuropathies: An Overview of Clinical Aspects, Pathogenesis, and Treatment / Aaron I. Vinik, Gary L. Pittenger, Patricia Barlow and Anahit Mehrabyan
  • 92. Diabetes Mellitus, Lipids, and Atherosclerosis / Clay F. Semenkovich
  • 93. Pathophysiology of Hypertension in Diabetes Mellitus / Naftali Stern, James Sowers and Michael L. Tuck
  • 94. Macrovascular Complications of Diabetes Mellitus / Helaine E. Resnick, Robert S. Lindsay and Barbara V. Howard
  • 95. Skin and Diabetes / Efrat Wertheimer
  • 96. Neonatal Diabetes Mellitus / Mark A. Sperling
  • 97. Hypoglycemia in the Adult / Monica C. Skarulis and Boaz Hirshberg
  • 98. Biochemistry and Molecular Cell Biology of Diabetic Complications: A Unifying Mechanism / Susanna Hofmann and Michael Brownlee
  • 99. Hyperinsulinemia and Insulin Resistance / Ele Ferrannini
  • 100. The Role of Growth Factors in the Pathogenesis of Diabetic Microvascular Complications / William L. Lowe, Jr.
  • 101. Oxidative Stress, Inflammation, and Diabetic Complications / Milagros G. Huerta and Jerry L. Nadler
  • 102. Diabetic Vasculopathy / S.I. McFarlane, P. Kumar, R. Muniyappa, F. El-Atat, A. Aneja and J.R. Sowers.