Evaluation of Enzyme Inhibitors in Drug Discovery : a Primer for Medicinal Chemists and Pharmacologists.

Most enzymology textbooks, including his own, address biochemists and other researchers, says Copeland, a researcher in enzymology and mechanistic pharmacology at a large pharmaceutical corporation. Here he provides chemists and pharmacologists with key information to answer such questions as what o...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Copeland, Robert Allen
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken : John Wiley & Sons, 2005.
Temas:
Enzyme inhibitors > Therapeutic use > Testing.
Drugs > Design.
Enzyme inhibitors > Structure-activity relationships.
Drug Design
Antienzymes > Emploi en thérapeutique > Essais.
Médicaments > Conception.
Antienzymes > Relations structure-activité.
Drugs > Design
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Evaluation of Enzyme Inhibitors in Drug Discovery Contents Foreword Preface Acknowledgments 1. Why Enzymes as Drug Targets? 2. Enzyme Reaction Mechanisms.
  • 3. Reversible Modes of Inhibitor Interactions with Enzymes 4. Assay Considerations for Compound Library Screening 5. Lead Optimization and Structure-Activity Relationships for Reversible Inhibitors.
  • 6. Slow Binding Inhibitors 7. Tight Binding Inhibitors 8. Irreversible Enzyme Inactivators Appendix 1. Kinetics of Biochemical Reactions.

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