Evaluation of Enzyme Inhibitors in Drug Discovery : a Primer for Medicinal Chemists and Pharmacologists.

Most enzymology textbooks, including his own, address biochemists and other researchers, says Copeland, a researcher in enzymology and mechanistic pharmacology at a large pharmaceutical corporation. Here he provides chemists and pharmacologists with key information to answer such questions as what o...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Copeland, Robert Allen
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken : John Wiley & Sons, 2005.
Temas:
Enzyme inhibitors > Therapeutic use > Testing.
Drugs > Design.
Enzyme inhibitors > Structure-activity relationships.
Drug Design
Antienzymes > Emploi en thérapeutique > Essais.
Médicaments > Conception.
Antienzymes > Relations structure-activité.
Drugs > Design
Acceso en línea:Texto completo

MARC

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505 0 |a Evaluation of Enzyme Inhibitors in Drug Discovery Contents Foreword Preface Acknowledgments 1. Why Enzymes as Drug Targets? 2. Enzyme Reaction Mechanisms. 
505 0 |a 3. Reversible Modes of Inhibitor Interactions with Enzymes 4. Assay Considerations for Compound Library Screening 5. Lead Optimization and Structure-Activity Relationships for Reversible Inhibitors. 
505 0 |a 6. Slow Binding Inhibitors 7. Tight Binding Inhibitors 8. Irreversible Enzyme Inactivators Appendix 1. Kinetics of Biochemical Reactions. 
520 |a Most enzymology textbooks, including his own, address biochemists and other researchers, says Copeland, a researcher in enzymology and mechanistic pharmacology at a large pharmaceutical corporation. Here he provides chemists and pharmacologists with key information to answer such questions as what opportunities for inhibitor interactions with enzym. 
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650 0 |a Drugs  |x Design. 
650 0 |a Enzyme inhibitors  |x Structure-activity relationships. 
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650 6 |a Médicaments  |x Conception. 
650 6 |a Antienzymes  |x Relations structure-activité. 
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