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Bacterial invasion of host cells /
Annotation Understanding the molecular basis of bacterial invasion and of host cell adaptation to intracellular bacteria will provide fundamental insights into the pathophysiology of bacteria and the cell biology of the host. This book details specific examples of bacteria that are masters of manipu...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge ; New York :
Cambridge University Press,
2004.
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| Colección: | Advances in molecular and cellular microbiology ;
5. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Half-title; Series-title; Title; Copyright; Contents; Contributors; Preface; Bacterial Invasion of Host Cells; CHAPTER 1 Invasion mechanisms of Salmonella; CLINICAL DESCRIPTION; SALMONELLA ENTRY: SALMONELLA PATHOGENICITY ISLAND-1; The regulation of Salmonella pathogenicity islands; The type III secretion complex; INTERNALIZATION OF SALMONELLA BY THE HOST EPITHELIUM; Animal models of Salmonella infection; Cell culture models of Salmonella infection; INVOLVEMENT OF THE HOST CELL CYTOSKELETON IN BACTERIAL INTERNALIZATION.
- INVOLVEMENT OF RHO GTPase IN S. TYPHIMURIUM INVASION OF NONPHAGOCYTIC CELLSS. TYPHIMURIUM GENES THAT REGULATE EPITHELIAL CELL INVASION; SopE/SopE2; SopB; SptP; SipC; SipA; ROLE OF SPI-1 IN PATHOGENESIS; HISTORICAL PERSPECTIVE OF SPI-1; REFERENCES; CHAPTER 2 Shigella invasion; INVASION; Shigella invasion and the host inflammatory responses; Basolateral entry into polarized cells; Invasion-associated genes on the large plasmid; Type III secretion system; Secreted effector proteins induce host cellular signaling; IpaA; IpaC; IpgD; VirA; CELL-CELL SPREADING; VirG; VirG ligands; N-WASP; Cdc42.
- Arp2/3Profilin; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 3 How Yersinia escapes the host: To Yop or not to Yop; THE YERSINIA VIRULENCE SYSTEM; Ysc-Yop III secretion system; Other virulence mechanisms and TTSS present in Yersinia species; FIRST CONTACT; Interaction of the enteropathogenic Y. enterocolitica and Y. pseudotuberculosis with M cells; Y. pestis enters the bloodstream immediately; HOW YERSINIA ESCAPES THE HOST: TO YOP OR NOT TO YOP; Inhibition of phagocytosis; YopE; YopT; YopO/YpkA; YopH; Inhibition of the inflammatory response and induction of apoptosis; YopP/J; YopH.
- Effectors other than Yops that help to defeat the immune responseYopM; CONCLUSION; REFERENCES; CHAPTER 4 Stealth warfare: The interactions of EPEC and EHEC with host cells; ADHERENCE MECHANISMS REQUIRED FOR INITIAL ATTACHMENT OF EPEC AND EHEC TO HOST CELLS; INTIMATE ATTACHMENT OF EHEC AND EPEC TO HOST CELLS, AND THE TYPE III SECRETORY APPARATUS; HOST CELL RESPONSES TO EHEC AND EPEC INFECTION; Pedestal formation; Inhibition of phagocytosis; Inhibition of mitosis; Disruption of tight junctions; Upregulation of chloride secretion and adenosine triphosphate (ATP) release; The Ca2+ controversy.
- Activation of mitogen-activated protein (MAP) kinase cascadesModulation of apoptosis; Disruption of mitochondrial membrane potential; Modulation of Cdc42 activity; Modification of host immune responses; Innate immunity; Adaptive immunity; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 Molecular ecology and cell biology of Legionella pneumophila; ECOLOGY OF LEGIONELLAE; ADHERENCE AND ENTRY MECHANISMS; Initial interactions between L. pneumophila and its primitive protozoan hosts; ATTACHMENT AND ENTRY TO MAMMALIAN CELLS; INTRACELLULAR TRAFFICKING.