Tabla de Contenidos:
  • Copper in Drinking Water
  • Copyright
  • Preface
  • Contents
  • Executive Summary
  • THE CHARGE TO THE COMMITTEE
  • THE COMMITTEE'S APPROACH TO ITS CHARGE
  • THE COMMITTEE'S EVALUATION
  • Health Effects of Excess Copper
  • Recommendations
  • Physiological Role of Copper
  • Recommendations
  • Sensitive Populations
  • Recommendations
  • Risk Characterization
  • Recommendations
  • 1 Introduction
  • CHEMICAL AND PHYSICAL PROPERTIES
  • SOURCES OF COPPER IN DRINKING WATER
  • COMMITTEE'S APPROACH TO ITS CHARGE
  • STRUCTURE OF THE REPORT
  • REFERENCES
  • 2 Physiological Role of CopperESSENTIALITY
  • BIOCHEMISTRY AND PHYSIOLOGY
  • FACTORS AFFECTING BIOAVAILABILITY
  • Effect of Age
  • Dietary and Other Interactions
  • CONCLUSIONS
  • RECOMMENDATIONS
  • REFERENCES
  • 3 Health Effects of Copper Deficiencies
  • TERATOGENESIS OF COPPER DEFICIENCY
  • Causes of Copper Deficiency
  • Copper in Prenatal Development
  • Drug-Induced Copper Deficiency
  • Disease-Induced Copper Deficiency
  • Copper-Diet Interactions
  • Gene-Induced Copper Deficiency
  • Human Copper Deficiency and Teratogenesis
  • Primary Dietary Copper DeficiencyHEALTH EFFECTS OF COPPER DEFICIENCIES IN ADULTS
  • CONCLUSIONS
  • REFERENCES
  • 4 Disorders of Copper Homeostasis
  • MENKES DISEASE
  • OCCIPITAL HORN SYNDROME
  • WILSON DISEASE
  • GENETIC CHARACTERISTICS OF WILSON AND MENKES DISEASES
  • HETEROZYGOTES FOR WILSON DISEASE
  • ACERULOPLASMINEMIA
  • TYROLEAN INFANTILE CIRRHOSIS
  • INDIAN CHILDHOOD CIRRHOSIS
  • IDIOPATHIC COPPER TOXICOSIS
  • OTHER GENETIC DISORDERS
  • DISEASE-INDUCED CHANGES IN COPPER HOMEOSTASIS
  • CONCLUSIONS
  • RECOMMENDATIONS
  • REFERENCES
  • 5 Health Effects of Excess CopperACUTE TOXICITY
  • Case Reports and Population-Based Studies
  • CHRONIC TOXICITY
  • Reproductive and Developmental Toxicity
  • Genotoxicity, Mutagenicity, and Carcinogenicity of Copper
  • Sensitive Populations
  • Carriers of Genetic Defects in Copper Homeostasis
  • Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD)
  • ANIMAL STUDIES
  • Toxicity in Animals
  • Reproductive and Developmental Toxicity
  • Neurotoxicity
  • Carcinogenicity
  • Mechanisms and Animal Models for Copper Toxicity
  • Mechanism of Acute Copper Toxicity
  • Mechanism of Chronic Copper ToxicityCONCLUSIONS
  • RECOMMENDATIONS
  • REFERENCES
  • 6 Risk Characterization
  • COPPER DEFICIENCY
  • COPPER TOXICITY FROM SINGLE OR SHORT-TERM EXPOSURE
  • COPPER TOXICITY FROM CHRONIC EXPOSURE
  • Sensitive Populations
  • Carriers of the Wilson-Disease Gene and Other Genetically Sensitive Groups
  • Infants
  • Chronic Liver Disease
  • Glucose-6-Phosphate Dehydrogenase Deficiency
  • Implications for the MCLG
  • CHRONIC COPPER EXPOSURE THROUGH TAP WATER
  • DIETARY CONTRIBUTION AND TOTAL COPPER INTAKE
  • Formula-Fed Infants