The Quest for the Cure : The Science and Stories Behind the Next Generation of Medicines /

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Stockwell, Brent (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Columbia University Press, [2011]
Temas:
Drug development.
Drugs > Design.
Proteins > Metabolism.
MEDICAL / Pharmacology.
Acceso en línea:Texto completo
Texto completo
Tabla de Contenidos:
  • Frontmatter
  • Contents
  • List of Illustrations
  • Preface
  • Acknowledgments
  • Abbreviations
  • Part One. The Vanishing Cures
  • 1. The Drug Discovery Crisis
  • 2. A New Science of Molecules
  • 3. The Birth of the First Cancer Drugs
  • 4. A New Company Creating Drug Combinations
  • 5. The Undruggable RAS Protein
  • 6.The Druggable Genome
  • Part Two. The Path to the Next Generation of Medicines
  • 7. Peering Inside Proteins
  • 8. The Nature of Interactions Between Proteins
  • 9. From Protein- Protein Interactions to Personalized Medicines
  • 10. A Revolution in Peptide Synthesis
  • 11. A Vast Array of Drug Candidates
  • 12. Moving Outside the Small Molecule Box
  • 13. Accelerating the Arrival of Next- Generation Drugs
  • Notes
  • Glossary
  • Index

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