Cargando…
Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene
Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes ident...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , , |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Singapore :
Springer Nature Singapore : Imprint: Springer,
2015.
|
| Edición: | 1st ed. 2015. |
| Colección: | SpringerBriefs in Forensic and Medical Bioinformatics,
|
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
| LEADER | 00000nam a22000005i 4500 | ||
|---|---|---|---|
| 001 | 978-981-4585-08-8 | ||
| 003 | DE-He213 | ||
| 005 | 20220423144413.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 140908s2015 si | s |||| 0|eng d | ||
| 020 | |a 9789814585088 |9 978-981-4585-08-8 | ||
| 024 | 7 | |a 10.1007/978-981-4585-08-8 |2 doi | |
| 050 | 4 | |a Q342 | |
| 072 | 7 | |a UYQ |2 bicssc | |
| 072 | 7 | |a TEC009000 |2 bisacsh | |
| 072 | 7 | |a UYQ |2 thema | |
| 082 | 0 | 4 | |a 006.3 |2 23 |
| 100 | 1 | |a Kashyap, Amita. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 245 | 1 | 0 | |a Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene |h [electronic resource] / |c by Amita Kashyap, D. Bujamma, Naresh Babu M. |
| 250 | |a 1st ed. 2015. | ||
| 264 | 1 | |a Singapore : |b Springer Nature Singapore : |b Imprint: Springer, |c 2015. | |
| 300 | |a VII, 72 p. 40 illus., 39 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a SpringerBriefs in Forensic and Medical Bioinformatics, |x 2196-8853 | |
| 505 | 0 | |a Introduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References. | |
| 520 | |a Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken. | ||
| 650 | 0 | |a Computational intelligence. | |
| 650 | 0 | |a Bioinformatics. | |
| 650 | 0 | |a Cancer. | |
| 650 | 0 | |a Biomedical engineering. | |
| 650 | 0 | |a Medical informatics. | |
| 650 | 0 | |a Engineering mathematics. | |
| 650 | 0 | |a Engineering-Data processing. | |
| 650 | 1 | 4 | |a Computational Intelligence. |
| 650 | 2 | 4 | |a Computational and Systems Biology. |
| 650 | 2 | 4 | |a Cancer Biology. |
| 650 | 2 | 4 | |a Biomedical Engineering and Bioengineering. |
| 650 | 2 | 4 | |a Health Informatics. |
| 650 | 2 | 4 | |a Mathematical and Computational Engineering Applications. |
| 700 | 1 | |a Bujamma, D. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 700 | 1 | |a Babu M, Naresh. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9789814585071 |
| 776 | 0 | 8 | |i Printed edition: |z 9789814585095 |
| 830 | 0 | |a SpringerBriefs in Forensic and Medical Bioinformatics, |x 2196-8853 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-981-4585-08-8 |z Texto Completo |
| 912 | |a ZDB-2-ENG | ||
| 912 | |a ZDB-2-SXE | ||
| 950 | |a Engineering (SpringerNature-11647) | ||
| 950 | |a Engineering (R0) (SpringerNature-43712) | ||