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Cancer Drug Discovery Science and History /
This book describes the history of cancer drugs development to provide insight into the successes and the shortcomings of this enterprise. Most cancer drug treatments target the cancer cell as the core component and as such are very effective in inhibiting their proliferation. However, these cancer...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , , , |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2016.
|
| Edición: | 1st ed. 2016. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Part Ⅰ. A Scientific Overview on Cancer
- 1. Advancements in Life Sciences and Characteristic Features of Cancer Cells
- 1.1 Characteristics of cancer cells
- 1.2 Characteristic interactions of cancer cells with neighboring cells and the tumor microenvironment
- 2. Advancement of the Science and History of Cancer and Anticancer Drugs
- Part Ⅱ. Cancer Drug Discovery - Types and History
- 3. Chronology of Anticancer Drug Development
- 3.1 A historical background of cancer chemotherapy
- 3.2 Development of the anticancer drug screening systems
- 3.3 Chronology of the anticancer drug development
- 3.4 Clinical application of anticancer drugs
- 4. Alkylating Anticancer Drugs
- 4.1 Classical alkylating drugs
- 4.2 Nonclassical alkylating drugs
- 4.3 Alkylating-like agents: platinum compounds
- 5. Antimetabolic Anticancer Drugs
- 5.1 Folic acid derivatives
- 5.2 Purine analogs
- 5.3 Pyrimidine analogs
- 6. Natural Product Anticancer Drugs
- 6.1 Plant-derived anticancer drugs
- 6.2 Anticancer antibiotics
- 7. Immunotherapeutic Anticancer Drugs and Other Miscellaneous Anticancer Drugs
- 7.1 Immunotherapeutic anticancer drugs
- 7.2 Other miscellaneous anticancer drugs
- 8. Hormonal Anticancer Drugs
- 8.1 Hormonal anti-prostate-cancer drugs
- 8.2 Hormonal anti-breast-cancer drugs
- 8.3 Other hormonal anticancer drugs
- 9. Molecular Targeted Anticancer Drugs
- 9.1 Tretinoin (all-trans retinoic acid, ATRA)
- 9.2 Bcr-Abl Inhibitors
- 9.3 EGFR inhibitors
- 9.4 HER2 inhibitors
- 9.5 Angiogenesis inhibitors
- 9.6 Other kinase inhibitors
- 9.7 mTOR inhibitors
- 9.8 Other targeted anticancer antibody drugs
- 9.9 Epigenetic anticancer drugs
- 9.10 Proteasome inhibitors
- 9.11 Vismodegib: hedgehog pathway blocker
- 10. Complications of Anticancer Drugs and Their Management
- 10.1 Chemotherapy-induced nausea and vomiting (CINV)
- 10.2 Myelotoxicity (bone marrow toxicity)
- 10.3 Chemotherapy-induced diarrhea
- 10.4 Chemotherapy-induced constipation
- 10.5 Chemotherapy-induced urinary toxicity
- 10.6 Chemotherapy-induced pulmonary toxicity
- 10.7 Chemotherapy-induced neurotoxicity
- 10.8 Chemotherapy-induced neurotoxicity
- 10.9 Chemotherapy-induced oral mucositis
- 10.10 Anorexia
- 10.11 Tumor lysis syndrome
- 10.12 Extravasation of anticancer drugs
- 10.13 Chemotherapy-induced skin toxicity
- Part Ⅲ. A Paradigm Shift in Cancer Research
- 11. Advancements in Bioscience and New Cancer Drugs
- 11.1. Development of cancer drugs according to scientific advancements
- 11.2. New anticancer drugs.