Multifaceted Roles of Crystallography in Modern Drug Discovery

The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosome...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Scapin, Giovanna (Editor ), Patel, Disha (Editor ), Arnold, Eddy (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Dordrecht : Springer Netherlands : Imprint: Springer, 2015.
Edición:1st ed. 2015.
Colección:NATO Science for Peace and Security Series A: Chemistry and Biology,
Temas:
Proteins .
Medicinal chemistry.
Medicine-Research.
Biology-Research.
Chemistry, Physical and theoretical.
Crystallography.
Protein Biochemistry.
Medicinal Chemistry.
Biomedical Research.
Theoretical Chemistry.
Crystallography and Scattering Methods.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Preface
  • List of Contributors
  • Engineering G Protein-Coupled Receptors for Drug Design
  • Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors
  • Epigenetic Drug Discovery
  • Crystallography and Biopharmaceuticals
  • Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors
  • Considerations for Structure-Based Drug Design Targeting HIV-1 Reverse Transcriptase.-Protein-Ligand Interactions as the Basis for Drug Action
  • The Protein Data Bank: Overview and Tools for Drug Discovery
  • Small Molecule Crystal Structures in Drug Discovery
  • Protein Aggregation and its Prediction
  • Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets
  • Protein-Protein Interactions: Structures and Druggability
  • Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design
  • Molecular Obesity, Potency and Other Addictions in Drug Discovery
  • Adventures in Small Molecule Fragment Screening by X-ray Crystallography for Drug Discovery
  • Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition
  • Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function.

Ejemplares similares