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Stress Response Pathways in Cancer From Molecular Targets to Novel Therapeutics /

It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Wondrak, Georg T. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Dordrecht : Springer Netherlands : Imprint: Springer, 2015.
Edición:1st ed. 2015.
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Preface
  • Introduction to cell stress responses in cancer: The big picture
  • DNA repair dysregulation in cancer: From molecular mechanisms to synthetic-lethal opportunities
  • Cell cycle checkpoint defects as anticancer targets: From molecular mechanisms to therapeutic opportunities
  • p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities
  • Sirtuins as a double-edged sword in cancer: From molecular mechanisms to therapeutic opportunities
  • MicroRNA regulated stress responses in cancer
  • Senescence in oncogenesis: From molecular mechanisms to therapeutic opportunities
  • Pro-senescence therapy for cancer: time for the clinic
  • Integrating proteotoxic stress response pathways for induction of cell death in cancer cells: molecular mechanisms and opportunities
  • The Hsp70 family of heat shock proteins in tumorigenesis: From molecular mechanisms to therapeutic opportunities
  • The ubiquitin-proteasome system (UPS) as a cancer drug target: Emerging mechanisms and therapeutics
  • Endoplasmatic reticulum stress in multiple myeloma: From molecular mechanisms to therapeutic opportunities
  • Melanomagenic gene alterations viewed from a redox perspective: Molecular mechanisms and therapeutic opportunities
  • Targeting hypoxic adaptations of cancer cells: Molecular mechanisms and therapeutic opportunities
  • Targeting glycolytic adaptations of cancer cells: from molecular mechanisms to therapeutic opportunities
  • At the crossroads between mitochondrial metabolite transport and apoptosis: VDAC1 as an emerging cancer drug target
  • Inflammatory dysregulation and cancer: From molecular mechanisms to therapeutic opportunities
  • Cell-nonautonomous ER stress-mediated dysregulation of immunity by cancer cells
  • Index.