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Translation and Its Regulation in Cancer Biology and Medicine
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, inc...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2014.
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| Edición: | 1st ed. 2014. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Preface
- Introduction
- PART I. TRANSALATION MACHINERY IN CANCER
- Mechanism of Translation in Eukaryotes
- Diverse Mechanisms of Translation Regulation and Their Role in Cancer
- eIF4E and Its Binding Proteins
- RNA Helicases and Their Cofactors
- PDCD4
- eIF4G
- eIF3
- The eIF2 Complex and eIF2α
- eIF5A
- eIF6
- Translation Elongation
- Ribosomes
- Current and Emerging Therapies Targeting Translation
- PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER
- mTOR and Regulation of Translation
- Ribosomal Protein S6 and S6 Kinases
- eIF4E Phosphorylation Downstream of MAPK Pathway
- PART III. CELL FATE AND TRANSLATION IN CANCER
- Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells
- Translation and Apoptosis in Cancer
- Translation in Cancer at Hypoxia
- PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES
- Melanoma and Non-Melanoma Skin Cancers
- Sarcomas
- Hematological Malignancies and Premalignant Conditions
- Brain Tumors
- Head and Neck Cancers
- Breast Cancer
- Cancers of the Respiratory System
- Gastric and Esophageal Cancers
- Colorectal Cancers
- Hepatic, Pancreatic and Biliary Cancers
- Pancreatic Neuroendocrine Tumors
- Gynecologic Cancers
- Prostate Cancer
- Cancers of the Urinary System
- List of Abbreviations.