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Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells
Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson's disease and spinal cord injury. There will also be many applications in drug development. Howeve...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2014.
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| Edición: | 1st ed. 2014. |
| Colección: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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|---|---|---|---|
| 001 | 978-94-017-8819-9 | ||
| 003 | DE-He213 | ||
| 005 | 20220117031200.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 140519s2014 ne | s |||| 0|eng d | ||
| 020 | |a 9789401788199 |9 978-94-017-8819-9 | ||
| 024 | 7 | |a 10.1007/978-94-017-8819-9 |2 doi | |
| 050 | 4 | |a QH588.S83 | |
| 072 | 7 | |a PSC |2 bicssc | |
| 072 | 7 | |a SCI017000 |2 bisacsh | |
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| 082 | 0 | 4 | |a 616.02774 |2 23 |
| 100 | 1 | |a Zhao, Xiaoyang. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 245 | 1 | 0 | |a Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells |h [electronic resource] / |c by Xiaoyang Zhao. |
| 250 | |a 1st ed. 2014. | ||
| 264 | 1 | |a Dordrecht : |b Springer Netherlands : |b Imprint: Springer, |c 2014. | |
| 300 | |a XV, 92 p. 21 illus., 18 illus. in color. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Springer Theses, Recognizing Outstanding Ph.D. Research, |x 2190-5061 | |
| 505 | 0 | |a Abstract -- Introduction -- Establishment of highly efficient somatic cell reprogramming system to generate iPSC lines- Establishment of highly efficient somatic cell reprogramming system and establishment of iPSC lines -- Pluripotency of iPSC and underlining mechanism -- Developmental potential of mouse iPSC -- Conclusions. | |
| 520 | |a Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson's disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species, and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications, and increase the current low induction efficiency of their production. | ||
| 650 | 0 | |a Stem cells. | |
| 650 | 0 | |a Cytology-Technique. | |
| 650 | 0 | |a Regenerative medicine. | |
| 650 | 0 | |a Developmental biology. | |
| 650 | 1 | 4 | |a Stem Cell Biology. |
| 650 | 2 | 4 | |a Cytological Techniques. |
| 650 | 2 | 4 | |a Regenerative Medicine and Tissue Engineering. |
| 650 | 2 | 4 | |a Developmental Biology and Stem Cells. |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9789401788205 |
| 776 | 0 | 8 | |i Printed edition: |z 9789401788182 |
| 776 | 0 | 8 | |i Printed edition: |z 9789402402261 |
| 830 | 0 | |a Springer Theses, Recognizing Outstanding Ph.D. Research, |x 2190-5061 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-94-017-8819-9 |z Texto Completo |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||