The Tumor Immunoenvironment

Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in t...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Shurin, Michael R. (Editor ), Umansky, Viktor (Editor ), Malyguine, Anatoli (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Dordrecht : Springer Netherlands : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Temas:
Cancer.
Oncology.
Immunology.
Life sciences.
Medicine-Research.
Biology-Research.
Cancer Biology.
Life Sciences.
Biomedical Research.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Preface
  • Introduction
  • Role of the immunological environment in cancer initiation, development and progression
  • Part I Tumor Microenvironment and Immunoenvironment
  • The metastatic microenvironment
  • Tumor infiltration by immune cells: pathologic evaluation and a clinical significance
  • Immunologic interpretation of cancer biology: impact on clinical outcome
  • Part II Developmental Characteristics of the Tumor ImmunoEnvironment
  • Development of antitumor cellular immunity
  • The versatile world of inflammatory chemokines in cancer.-Inflammation, Tumor Progression, and Immune Suppression
  • Pleiotropic and differential functions of IL-1a and IL-1b shape the tumor microenvironment and affect the outcome of malignancies
  • Impact of obesity and aging on the tumor immunoenvironment
  • Part III Tumor Escape from Immune Recognition
  • MHC class I antigens and the tumor microenvironment
  • Tumor-produced immune regulating factors
  • Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments.- T cell malfunction in the tumor environment
  • Signaling of tumor-induced immunosuppression of dendritic cells
  • Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells
  • Part IV  Immune Regulators in the Tumor ImmunoEnvironment
  • The role of myeloid-derived suppressor cells in cancer
  • Macrophage differentiation and activation states in the tumor microenvironment
  • Dendritic cells and cancer: development, dysfunction and therapeutic targets
  • The role of tumor-associated neutrophils in cancer
  • Mast cell modulation of the tumor microenvironment
  • Regulatory T cells in patients with cancer
  • Tumor-evoked regulatory B cells as important mediators of cancer escape
  • Part V  Tumor Escape and Cancer Immunotherapy
  • Cancer immunotherapy: Overview in brief
  • Programming of MDSC: New opportunities for targeted therapy
  • Therapeutic targeting regulatory T cells in tumor.-ChemoImmunoModulation: Focus on myeloid regulatory cells
  • Combining vaccines with therapies that render tumor cells more susceptible to        immune mediated killing
  • Prophylactic Cancer Vaccines
  • Part VI  Analyzing Immune Responses in Cancer
  • Approaches to Immunologic Monitoring of Clinical Trials
  • Evaluation of the tumor immunoenvironment in clinical trials
  • Analysis of Myeloid-derived Suppressor Cells in Patients with Cancer
  • When results of T cell immune monitoring match or do not match clinical outcomes of tumor vaccine trials - what more could and should we measure?

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