Cargando…

GAPDH: Biological Properties and Diversity

GAPDH (glyceraldehyde 3-phosphate dehydrogenase) is more than just a glycolytic enzyme. An unprecedented amount of literature demonstrates that GAPDH has an astounding multiplicity of function. This diversity is not simply due to cell compartmentation (i.e. redistributing glycolytic energy to where...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Seidler, Norbert W. (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Dordrecht : Springer Netherlands : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Colección:Advances in Experimental Medicine and Biology, 985
Temas:
Acceso en línea:Texto Completo

MARC

LEADER 00000nam a22000005i 4500
001 978-94-007-4716-6
003 DE-He213
005 20220118035537.0
007 cr nn 008mamaa
008 120731s2013 ne | s |||| 0|eng d
020 |a 9789400747166  |9 978-94-007-4716-6 
024 7 |a 10.1007/978-94-007-4716-6  |2 doi 
050 4 |a R850.A1-854 
050 4 |a QH315-320 
072 7 |a MBGR  |2 bicssc 
072 7 |a MED000000  |2 bisacsh 
072 7 |a MBGR  |2 thema 
082 0 4 |a 610.72  |2 23 
100 1 |a Seidler, Norbert W.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
245 1 0 |a GAPDH: Biological Properties and Diversity  |h [electronic resource] /  |c by Norbert W. Seidler. 
250 |a 1st ed. 2013. 
264 1 |a Dordrecht :  |b Springer Netherlands :  |b Imprint: Springer,  |c 2013. 
300 |a XIV, 295 p. 96 illus., 8 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
490 1 |a Advances in Experimental Medicine and Biology,  |x 2214-8019 ;  |v 985 
520 |a GAPDH (glyceraldehyde 3-phosphate dehydrogenase) is more than just a glycolytic enzyme. An unprecedented amount of literature demonstrates that GAPDH has an astounding multiplicity of function. This diversity is not simply due to cell compartmentation (i.e. redistributing glycolytic energy to where it is needed), although this feature is undoubtedly important and discussed in the book. GAPDH integrates glycolysis with other cellular processes. This concept of integration cannot be understated. But, there is more. GAPDH actively participates in numerous non-glycolytic cellular events that fall into very broad categories including the cell infrastructure and the transmission of genetic information. Some of GAPDH's biological properties are completely non-intuitive given the current undergraduate textbook understanding of this glycolytic enzyme. For example, GAPDH binds to select phospholipids and catalyzes organelle biogenesis. It has fusogenic properties, enabling it to be actively involved in nuclear envelop reassembly, autophagy and membrane trafficking. Human macrophages exhibit surface-localized GAPDH with receptor function. As scientists, we are trained to consider GAPDH as a soluble cytosolic dehydrogenase enzyme. The literature observations - as described in this book - tell us something quite different. Besides oxidoreductase activity, GAPDH exhibits peroxidase, uracil DNA glycosylase, nitrosylase, mono-ADP-ribosylase, esterase and phosphotransferase activity. GAPDH binds membrane transport proteins, G-proteins, poly-nucleotides, adenines, specific lipids, select carbohydrates, cytoskeletal proteins, nuclear import and export proteins, diverse ATPases, molecular chaperones and other molecules. 
650 0 |a Medicine-Research. 
650 0 |a Biology-Research. 
650 0 |a Biochemistry. 
650 0 |a Chemistry. 
650 1 4 |a Biomedical Research. 
650 2 4 |a Biochemistry. 
650 2 4 |a Chemistry. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
776 0 8 |i Printed edition:  |z 9789400747173 
776 0 8 |i Printed edition:  |z 9789400747159 
776 0 8 |i Printed edition:  |z 9789402406290 
830 0 |a Advances in Experimental Medicine and Biology,  |x 2214-8019 ;  |v 985 
856 4 0 |u https://doi.uam.elogim.com/10.1007/978-94-007-4716-6  |z Texto Completo 
912 |a ZDB-2-SBL 
912 |a ZDB-2-SXB 
950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708)