Modelling of GPCRs A Practical Handbook /

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is -...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Strasser, Andrea (Autor), Wittmann, Hans-Joachim (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Dordrecht : Springer Netherlands : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Temas:
Medicine-Research.
Biology-Research.
Bioinformatics.
Computer simulation.
Medicinal chemistry.
Biomedical Research.
Computational and Systems Biology.
Computer Modelling.
Medicinal Chemistry.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Preface
  • 1. Introduction
  • 2. G Protein Coupled Receptors
  • 3. Sequence alignment and homology modelling
  • 4. Construction of ligands
  • 5. Lipids
  • 6. Minimization and molecular dynamics.- 7. Calculation of Gibbs energy of salvation
  • 8. Special topics in GPCR research
  • 9. Force fields
  • 10. Thermodynamics of ligand-receptor interaction
  • 11. Important LINUX commands
  • Literature
  • Appendix
  • Index.

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