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Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases
Aberrant protein folding and self-assembly underlie over 30 human diseases called amyloidoses, for which currently there is no cure. The diseases range from tissue-specific to systemic and from genetic to sporadic. Some of the most devastating amyloidoses are those that affect the central nervous sy...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2012.
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| Edición: | 1st ed. 2012. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- 1. Overview of Fibrillar and Oligomeric Assemblies of Amyloidogenic Proteins
- 2. Pathologic Lesions in Alzheimer disease and Other Neurodegenerative Diseases-Cellular and Molecular Components
- 3. Preparation and Structural Characterization of Pre-fibrillar Assemblies of Amyloidogenic Proteins
- 4. Biological Targeting and Activity of Pre-fibrillar Aβ Assemblies
- 5. The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer's disease
- 6. Oligomers of α-Synuclein in the Pathogenesis of Parkinson's Disease
- 7. Cytotoxic Mechanisms of Islet Amyloid Polypeptide in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM)
- 8. Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis
- 9. Structural Studies of Prion Proteins and Prions
- 10. Role of Prion Protein Oligomers in the Pathogenesis of Transmissible Spongiform Encephalopathies
- 11. When More Is Not Better: Expanded Polyglutamine Domains in Neurodegenerative Disease
- 12. Protein Misfolding and Toxicity in Dialysis-Related Amyloidosis
- 13. Transthyretin Aggregation and Toxicity
- 14. Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases.