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Sarcopenia - Age-Related Muscle Wasting and Weakness Mechanisms and Treatments /

Some of the most serious consequences of aging are its effects on skeletal muscle. 'Sarcopenia', the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their f...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Lynch, Gordon S. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Dordrecht : Springer Netherlands : Imprint: Springer, 2011.
Edición:1st ed. 2011.
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • 1.Overview
  • 2. Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia
  • 3. Age-related remodeling of neuromuscular junctions
  • 4.Motor unit remodeling during aging
  • 5. Age-related decline in actomyosin structure and function
  • 6. Excitation-contraction coupling in aged skeletal muscle
  • 7. Mitochondrial function in aging skeletal muscle
  • 8. Fibrosis and skeletal muscle aging
  • 9. Nuclear apoptosis and sarcopenia
  • 10. Age-related changes in the molecular regulation of skeletal muscle mass
  • 11. Genetic variation and skeletal muscle traits: implications for sarcopenia
  • 12. Proteomic profiling of aged skeletal muscle
  • 13. Aging, exercise and muscle protein metabolism
  • 14. Reactive oxygen species generation and skeletal muscle wasting - implications for sarcopenia
  • 15. Exercise as a countermeasure for sarcopenia
  • 16. Role of contraction-induced injury in age-related muscle wasting and weakness
  • 17. Role of IGF-I signaling in age-related changes in skeletal muscle
  • 18. Role of myostatin and TGF-beta signaling in skeletal muscle growth and development: implications for sarcopenia
  • 19. β-Adrenergic signaling in sarcopenia and other muscle wasting disorders.