Protein Modifications in Pathogenic Dysregulation of Signaling

This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Inoue, Jun-ichiro (Editor ), Takekawa, Mutsuhiro (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Tokyo : Springer Japan : Imprint: Springer, 2015.
Edición:1st ed. 2015.
Temas:
Proteins .
Cytology.
Cancer.
Protein Biochemistry.
Cell Biology.
Cancer Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Preface
  • Part I Novel Analytical Procedures for Signal Transduction
  • 1 Phosphoproteomics-based Network Analysis of Cancer Cell Signaling Systems (Hiroko Kozuka-Hata and Masaaki Oyama)
  • 2 Phos-tag-based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome (Eiji Kinoshita, Emiko Kinoshita-Kikuta, and Tohru Koike)
  • 3 Visualization of Intracellular Signaling with Fluorescence Resonance Energy Transfer-based Biosensors (Kazuhiro Aoki)
  • 4 Technology of Wheat Cell-free Based Protein Array for Biochemical Analyses of Protein Kinases and Ubiquitin E3 Ligases (Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, and Tatsuya Sawasaki)
  • Part II Mathematical Simulation of Signal Transduction
  • 5 Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations (Daisuke Ohshima, Jun-ichiro Inoue, and Kazuhisa Ichikawa)
  • 6 Stochastic Simulation of Stress Granules (Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, and Kazuhisa Ichikawa)
  • 7 Temporal Coding of Insulin Signaling (Hiroyuki Kubota and Shinya Kuroda)
  • Part III Structural Analysis of Signal Transduction
  • 8 Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling (Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, and Ryuichiro Ishitani)
  • 9 Structural Basis for the Signal Initiation by TNF and TNFR (Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, and Yuriko Yamagata)
  • 10 Regulation of NF-κB Pathway by Linkage-specific Ubiquitin-binding Domains (Yusuke Sato)
  • Part IV Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation
  • 11 NF-κB Signaling and Lymphoid Malignancies (Shoji Yamaoka)
  • 12 Ubiquitination-mediated NF-κB Regulation in Inflammatory Response (Fuminori Tokunaga)
  • 13 NF-κB Signaling in Osteoclastogenesis (Yuu Taguchi, Jin Gohda, and Jun-ichiro Inoue)
  • 14 Mitogen-activated Protein Kinase Signaling and Cancer (Mutsuhiro Takekawa and Yuji Kubota)
  • 15 Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression (Atsushi Enomoto, Liang Weng, and Masahide Takahashi)
  • 16 Protein Modifications Pace the Circadian Oscillation of Biological Clocks (Hikari Yoshitane and Yoshitaka Fukada)
  • 17 Keap1-Nrf2 Regulatory System and Cancer (Keiko Taguchi and Masayuki Yamamoto)
  • 18 Actin Filament Formation in Myofibrils and Cell Protrusions Regulated by Signal Transduction (Takeshi Endo and Kazunori Takano)
  • 19 Molecular Signaling and its Pathogenic Alterations in Neuromuscular Junction Formation and Maintenance (Ryo Ueta and Yuji Yamanashi)
  • 20 Post-translational Modification of Tcf/Lef: New Insights into the Regulation of Wnt/β-catenin Signaling (Tohru Ishitani)
  • BM Index.

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