Cargando…

Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53

This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a k...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Kamada, Rui (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Tokyo : Springer Japan : Imprint: Springer, 2012.
Edición:1st ed. 2012.
Colección:Springer Theses, Recognizing Outstanding Ph.D. Research,
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Quantitative analysis for p53 tetramerization domain mutants reveals a low threshold for tumor suppressor inactivation
  • Stabilization of mutant tetrameric structures by calixarene derivatives
  • Inhibition of the transcriptional activity of p53 through hetero-oligomerization.