Cargando…
The Immune Synapse as a Novel Target for Therapy
The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell-APC junction. It plays an essential role in the control and nature...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Basel :
Birkhäuser Basel : Imprint: Birkhäuser,
2008.
|
| Edición: | 1st ed. 2008. |
| Colección: | Progress in Inflammation Research,
|
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- The immune synapse and T cell activation: regulation by chemokines
- The induction of regulatory T cells by targeting the immune synapse
- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology
- Targeting CD4 for the induction of dominant tolerance
- Anti-CD3: from T cell depletion to tolerance induction
- Immune modulation by CD40L blockade
- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
- Adhesion molecules as therapeutic targets
- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?
- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells
- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance
- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.