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Adhesion Molecules: Function and Inhibition

Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most rel...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Ley, Klaus (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2007.
Edición:1st ed. 2007.
Colección:Progress in Inflammation Research,
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Capture and rolling
  • P-selectin glycoprotein ligand-1 (PSGL-1)
  • L-selectin-mediated leukocyte adhesion and migration
  • P- and E-selectin
  • Firm adhesion
  • Endothelial ICAM-1 functions in adhesion and signaling during leukocyte recruitment
  • ?4-integrins: structure, function and secrets
  • VCAM-1 and its functions in development and inflammatory diseases
  • Lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (Mac-1): Cooperative partners in leukocyte emigration and function
  • Transendothelial migration
  • PECAM: Regulating the start of diapedesis
  • Role of ?6?1 integrin in leukocyte adhesion and transmigration
  • Vascular adhesion protein-1 (VAP-1)
  • The role of endothelial cell-selective adhesion molecule (ESAM) in neutrophil emigration into inflamed tissues
  • Structure and function of JAM proteins
  • Promises and limitations of targeting adhesion molecules for therapy.