Imaging in Drug Discovery and Early Clinical Trials

The impact of genomics on biomedical research and the development of efficient technology platforms allowing for highly parallel compound synthesis and screening procedures have led to a major paradigm shift in drug discovery and development. Efficient tools for the selection and validation of drug...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Rudin, Markus (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2005.
Edición:1st ed. 2005.
Colección:Progress in Drug Research, 62
Temas:
Radiology.
Control engineering.
Robotics.
Automation.
Control, Robotics, Automation.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • The drug discovery process
  • Imaging modalities: principles and information content
  • Magnetic resonance and fluorescence based molecular imaging technologies
  • Studying molecular and cellular processes in the intact organism
  • Disease phenotyping: structural and functional readouts
  • Evaluation of drug candidates: Efficacy readouts during lead optimization
  • Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities
  • Pharmacokinetic studies with PET
  • Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development
  • Clinical drug evaluation using imaging readouts: regulatory perspectives.

Ejemplares similares