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The Hereditary Basis of Rheumatic Diseases
Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part de...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Basel :
Birkhäuser Basel : Imprint: Birkhäuser,
2006.
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| Edición: | 1st ed. 2006. |
| Colección: | Progress in Inflammation Research,
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| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Genetics of joint inflammation - problems and possibilities
- Genetic studies on rheumatic diseases
- The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes
- Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine
- Gene-based large scale LD-mapping of rheumatoid arthritis-associated genes
- Shared heredity of rheumatic diseases
- Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders
- Shared genes in rheumatic diseases, the role of PD1 and the RUNX genes in disease susceptibility
- The role of B27 and other genes associated with ankylosing spondylitis
- Tools for analysing complexity
- Emerging tools for dissecting complex disease
- Expression analysis of rheumatic diseases, prospects and problems
- The use of humanized MHC mouse strains for studies of rheumatic diseases
- SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells
- A genetic approach to select and validate new targets for treatment of rheumatic diseases.