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Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and a...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Basel :
Birkhäuser Basel : Imprint: Birkhäuser,
2005.
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| Edición: | 1st ed. 2005. |
| Colección: | Progress in Inflammation Research,
|
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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| 024 | 7 | |a 10.1007/3-7643-7379-2 |2 doi | |
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| 245 | 1 | 0 | |a Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation |h [electronic resource] / |c edited by Annika B. Malmberg, Keith R. Bley. |
| 250 | |a 1st ed. 2005. | ||
| 264 | 1 | |a Basel : |b Birkhäuser Basel : |b Imprint: Birkhäuser, |c 2005. | |
| 300 | |a XII, 249 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 490 | 1 | |a Progress in Inflammation Research, |x 2296-4525 | |
| 505 | 0 | |a Historical perspective on capsaicin and its receptor -- Hot peppers, pain and analgesics -- Molecular and cellular properties of vanilloid receptors -- Structural determinants of TRPV1 functionality -- TRPV1 distribution and regulation -- Pharmacology and physiology of vanilloid receptors -- Insights into TRPV1 pharmacology provided by non-capsaicin ligands -- Endocannabinoids and vanilloid TRPV1 receptors -- Vanilloid receptor-mediated hyperalgesia and desensitization -- Capsaicin in human experimental pain models of skin, muscle and visceral sensitization -- Vanilloid receptor involvement in disease states -- TRPV1 in gut function, abdominal pain and functional bowel disorders -- TRPV1 in the airways -- Therapeutic potential of vanilloid agonists and antagonists -- TRPV1 agonist-based therapies: mechanism of action and clinical prospects -- TRPV1 agonist therapies in bladder diseases -- TRPV1 antagonists and chronic pain. | |
| 520 | |a Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema. | ||
| 650 | 0 | |a Pain medicine. | |
| 650 | 0 | |a Immunology. | |
| 650 | 0 | |a Neurosciences. | |
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Cytology. | |
| 650 | 1 | 4 | |a Pain Medicine. |
| 650 | 2 | 4 | |a Immunology. |
| 650 | 2 | 4 | |a Neuroscience. |
| 650 | 2 | 4 | |a Pharmacology. |
| 650 | 2 | 4 | |a Cell Biology. |
| 700 | 1 | |a Malmberg, Annika B. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Bley, Keith R. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783764390259 |
| 776 | 0 | 8 | |i Printed edition: |z 9783764370800 |
| 830 | 0 | |a Progress in Inflammation Research, |x 2296-4525 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/3-7643-7379-2 |z Texto Completo |
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| 950 | |a Medicine (SpringerNature-11650) | ||
| 950 | |a Medicine (R0) (SpringerNature-43714) | ||