Proteases: Structure and Function

Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis....

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Brix, Klaudia (Editor ), Stöcker, Walter (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Vienna : Springer Vienna : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Temas:
Enzymology.
Proteins.
Proteins .
Protein Biochemistry.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • 1 Protease families, evolution and mechanisms of action "Set the stage"
  • 1.1 Enzyme families, prototypes and catalytic mechanisms
  •  1.2 Enzyme kinetics, mathematical modelling and perspectives
  •  1.3 Structure determination and search for inhibitors
  • 2 Regulation of proteolysis "Positioning and teaming-up to control activity"
  • 2.1 Compartmentalization of proteolysis
  • 2.2 Biosynthesis of lysosomal proteases
  • 2.3 Interactions of proteases and inhibitors / networking in the degradome
  • 2.4 In vivo analysis of the protease and inhibitors concert
  • 3 Proteases in development "Born to be right"
  • 3.1 Proteases for pattern formation during morphogenesis
  • 3.2 Proteases in death pathways (apoptosis, necrosis)
  • 4 Proteases in physiology and pathophysiology "Cleave to function in health or to cause disease"
  • 4.1 Protein turnover and signaling functions (degrade to rebuild, remodel, process and mature for signalling)
  • 4.2 Proteases in control of physiology
  • 4.3 Cancer: invasion and metastasis
  • 4.4 Bacterial proteases
  • 4.5 Viral proteases.

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