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Developments in Statistical Evaluation of Clinical Trials
This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials. Over the past few decades the role of statistics in the evaluation and interpretation of clinical d...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2014.
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| Edición: | 1st ed. 2014. |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Preface
- List of contributors
- 1.Statistical Models and Methods for Incomplete Data in Randomized Clinical Trials. M.A. McIsaac and R.J. Cook
- 2.Bayesian Decision Theory and the Design and Analysis of Randomized Clinical Trials. A.R. Willan
- 3.Designing Multi-Arm Multi-Stage Clinical Studies. T.Jaki
- 4.Statistical Approaches to Improving Trial Efficiency and Conduct. J.Pogue, P. J. Devereaux and S.Yusuf
- 5.Competing Risk and Survival Analysis. K.van Montfort, P.Fennema and W.Ghidey.- 6.Recent Developments in Group-Sequential Designs. J.M. S. Wason
- 7.Statistical Inference for Non-Inferiority of a Diagnostic Procedure Compared to an Alternative Procedure, Based on the Difference in Correlated Proportions from Multiple Raters. H.Saeki and T.Tango
- 8.Design and Analysis of Clinical Trial Simulations. K.Kuribayashi
- 9.Causal Effect Estimation and Dose Adjustment in Exposure-Response Relationship Analysis. J.Wang
- 10.Different Methods to Analyse Results of a Randomised Controlled Trial with More Than one Follow-up Measurement. J.W. R. Twisk
- 11.Statistical Methods for the Assessment of Clinical Relevance. M.Kieser
- 12.Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses. R.J. Cook and K.-A.Lee
- 13.Statistical Validation of Surrogate Markers in Clinical Trials. A.Alonso, G.Molenberghs and G.van Breukelen
- 14.Biomarker-Based Designs of Phase III Clinical Trials for Personalized Medicine. S.Matsui, T.Nonaka and Y.Choai
- 15.Dose-Finding Models for Two-Agent Combination Phase I Trials. A.Hirakawa and S.Matsui
- 16.Multi-State Models Used in Oncology Trials. B.Gaschler-Markefski, K.Schiefele, J.Hocke and F.Fleischer
- 17.Review of Designs for Accommodating Patients' or Physicians' Preferences in Randomized Controlled Trials. A.S. Ismaila and S.D. Walter
- 18.Dose Finding Methods in Oncology: From the Maximum Tolerated Dose to the Recommended Phase II Dose. X.Paoletti and A.Doussau.