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Voltage Gated Sodium Channels
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium chann...
| Clasificación: | Libro Electrónico |
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| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2014.
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| Edición: | 1st ed. 2014. |
| Colección: | Handbook of Experimental Pharmacology,
221 |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Overview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels
- Slow inactivation of Na+ channels
- Regulation/modulation of sensory neuron sodium channels
- Ubiquitylation of voltage-gated sodium channels
- Probing gating mechanisms of sodium channel using pore blockers
- Animal toxins influence voltage-gated sodium channel function
- Voltage-sensor trapping toxins: Iso form-specific ligands for sodium channels
- Pharmacological insights and quirks of bacterial sodium channels
- The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels
- The role of late INa in development of cardiac arrhythmias
- Proton modulation of cardiac INa: A potential arrhythmogenic trigger
- Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents. .