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Disruption of Protein-Protein Interfaces In Search of New Inhibitors /
"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian r...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2013.
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| Edición: | 1st ed. 2013. |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
| LEADER | 00000nam a22000005i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-37999-4 | ||
| 003 | DE-He213 | ||
| 005 | 20220118190411.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 130703s2013 gw | s |||| 0|eng d | ||
| 020 | |a 9783642379994 |9 978-3-642-37999-4 | ||
| 024 | 7 | |a 10.1007/978-3-642-37999-4 |2 doi | |
| 050 | 4 | |a QD241-441 | |
| 072 | 7 | |a PNN |2 bicssc | |
| 072 | 7 | |a SCI013040 |2 bisacsh | |
| 072 | 7 | |a PNN |2 thema | |
| 082 | 0 | 4 | |a 547 |2 23 |
| 245 | 1 | 0 | |a Disruption of Protein-Protein Interfaces |h [electronic resource] : |b In Search of New Inhibitors / |c edited by Stefano Mangani. |
| 250 | |a 1st ed. 2013. | ||
| 264 | 1 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg : |b Imprint: Springer, |c 2013. | |
| 300 | |a VII, 161 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 505 | 0 | |a Drug discovery by targeting protein-protein interactions -- Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds -- Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields -- NMR as a tool to target protein-protein interactions -- Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes -- Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences. | |
| 520 | |a "Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces. | ||
| 650 | 0 | |a Chemistry, Organic. | |
| 650 | 1 | 4 | |a Organic Chemistry. |
| 700 | 1 | |a Mangani, Stefano. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783642433894 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642380006 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642379987 |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-3-642-37999-4 |z Texto Completo |
| 912 | |a ZDB-2-CMS | ||
| 912 | |a ZDB-2-SXC | ||
| 950 | |a Chemistry and Materials Science (SpringerNature-11644) | ||
| 950 | |a Chemistry and Material Science (R0) (SpringerNature-43709) | ||