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Protein-Nanoparticle Interactions The Bio-Nano Interface /

In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technologi...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Rahman, Masoud (Autor), Laurent, Sophie (Autor), Tawil, Nancy (Autor), Yahia, L'Hocine (Autor), Mahmoudi, Morteza (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Colección:Springer Series in Biophysics, 15
Temas:
Acceso en línea:Texto Completo

MARC

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245 1 0 |a Protein-Nanoparticle Interactions  |h [electronic resource] :  |b The Bio-Nano Interface /  |c by Masoud Rahman, Sophie Laurent, Nancy Tawil, L'Hocine Yahia, Morteza Mahmoudi. 
250 |a 1st ed. 2013. 
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300 |a X, 86 p.  |b online resource. 
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490 1 |a Springer Series in Biophysics,  |x 1868-2561 ;  |v 15 
505 0 |a The Biological Significance of 'Nano' interactions -- Nanoparticle and Protein Corona -- Protein Corona: Applications and Challenges -- Analytical Methods for Corona Evaluations. 
520 |a In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a "biological identity" to their surfaces (referred to as a "corona"), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called "bio-nano interface," has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts. 
650 0 |a Biochemistry. 
650 0 |a Proteins . 
650 0 |a Pharmacology. 
650 0 |a Biophysics. 
650 0 |a Nanoscience. 
650 0 |a Nanotechnology. 
650 1 4 |a Biochemistry. 
650 2 4 |a Protein Biochemistry. 
650 2 4 |a Pharmacology. 
650 2 4 |a Biophysics. 
650 2 4 |a Nanophysics. 
650 2 4 |a Nanotechnology. 
700 1 |a Laurent, Sophie.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Tawil, Nancy.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Yahia, L'Hocine.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
700 1 |a Mahmoudi, Morteza.  |e author.  |4 aut  |4 http://id.loc.gov/vocabulary/relators/aut 
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