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Metallocorroles for Attenuation of Atherosclerosis
Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atheroscler...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2012.
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| Edición: | 1st ed. 2012. |
| Colección: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- Biologically relevant ROS/RNS
- Atherosclerosis
- The pro-atherogenic role of LDL and macrophages
- The anti-atheroginicity of HDL
- Common treatments for atherosclerosis
- Corroles
- Catalytic antioxidants
- Electronic spectra
- Research Goals
- Results
- Interactions of corroles with lipoproteins
- Corrole-lipoproteins binding
- Corrole distribution in serum
- Spectral changes in the presence of lipoprotein components
- The effect of corroles on oxidative-stress-induced lipoprotein damage
- Cu+2-induced oxidation
- Peroxynitrite-induced oxidation
- Lipoprotein function
- Interactions of corroles with macrophages
- Fluorescence-based detection of 1-Ga
- Chemiluminescence-based detection of 1-Fe
- Cellular accumulation of 1-Fe versus iron(III) porphyrins
- The effect of corroles on macrophage atherogenicity
- Effect on oxidative-stress-induced cell death
- Effect on macrophages cholesterol metabolism.-The effect of corroles on the development of atherosclerosis
- Discussion
- Interaction of corroles with lipoproteins
- Corrole distribution in serum
- Mode of 1-Fe binding to lipoproteins
- Materials and Methods.