Heteroaromatic Lipoxin A4 Analogues Synthesis and Biological Evaluation /

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines kno...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Duffy, Colm (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012.
Edición:1st ed. 2012.
Colección:Springer Theses, Recognizing Outstanding Ph.D. Research,
Temas:
Bioorganic chemistry.
Biochemistry.
Medicinal chemistry.
Catalysis.
Bioorganic Chemistry.
Medicinal Chemistry.
Acceso en línea:Texto Completo

MARC

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245 1 0 |a Heteroaromatic Lipoxin A4 Analogues  |h [electronic resource] :  |b Synthesis and Biological Evaluation /  |c by Colm Duffy. 
250 |a 1st ed. 2012. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg :  |b Imprint: Springer,  |c 2012. 
300 |a XXII, 130 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
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490 1 |a Springer Theses, Recognizing Outstanding Ph.D. Research,  |x 2190-5061 
505 0 |a Introduction -- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues -- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues -- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues -- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines -- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues. 
520 |a In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation. 
650 0 |a Bioorganic chemistry. 
650 0 |a Biochemistry. 
650 0 |a Medicinal chemistry. 
650 0 |a Catalysis. 
650 1 4 |a Bioorganic Chemistry. 
650 2 4 |a Biochemistry. 
650 2 4 |a Medicinal Chemistry. 
650 2 4 |a Catalysis. 
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830 0 |a Springer Theses, Recognizing Outstanding Ph.D. Research,  |x 2190-5061 
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950 |a Chemistry and Materials Science (SpringerNature-11644) 
950 |a Chemistry and Material Science (R0) (SpringerNature-43709) 

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