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Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2012.
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| Edición: | 1st ed. 2012. |
| Colección: | Springer Theses, Recognizing Outstanding Ph.D. Research,
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| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
| LEADER | 00000nam a22000005i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-23988-5 | ||
| 003 | DE-He213 | ||
| 005 | 20220114111807.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 110929s2012 gw | s |||| 0|eng d | ||
| 020 | |a 9783642239885 |9 978-3-642-23988-5 | ||
| 024 | 7 | |a 10.1007/978-3-642-23988-5 |2 doi | |
| 050 | 4 | |a QH505 | |
| 072 | 7 | |a PHVN |2 bicssc | |
| 072 | 7 | |a SCI009000 |2 bisacsh | |
| 072 | 7 | |a PHVN |2 thema | |
| 082 | 0 | 4 | |a 571.4 |2 23 |
| 100 | 1 | |a Guseva, Ksenia. |e author. |4 aut |4 http://id.loc.gov/vocabulary/relators/aut | |
| 245 | 1 | 0 | |a Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane |h [electronic resource] / |c by Ksenia Guseva. |
| 250 | |a 1st ed. 2012. | ||
| 264 | 1 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg : |b Imprint: Springer, |c 2012. | |
| 300 | |a XII, 80 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Springer Theses, Recognizing Outstanding Ph.D. Research, |x 2190-5061 | |
| 505 | 0 | |a Introduction -- The Role of Fragmentation on the Formation of Homomeric Protein Complexes -- Collective Response of Self-organised Clusters of Mechanosensitive Channels -- Assembly and Fragmentation of Tat Pores -- Conclusion. | |
| 520 | |a With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process. | ||
| 650 | 0 | |a Biophysics. | |
| 650 | 0 | |a Biological transport. | |
| 650 | 0 | |a Cell membranes. | |
| 650 | 0 | |a System theory. | |
| 650 | 0 | |a Polymers. | |
| 650 | 0 | |a Mathematical physics. | |
| 650 | 1 | 4 | |a Biophysics. |
| 650 | 2 | 4 | |a Membrane Trafficking. |
| 650 | 2 | 4 | |a Complex Systems. |
| 650 | 2 | 4 | |a Polymers. |
| 650 | 2 | 4 | |a Theoretical, Mathematical and Computational Physics. |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783642269943 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642239878 |
| 776 | 0 | 8 | |i Printed edition: |z 9783642239892 |
| 830 | 0 | |a Springer Theses, Recognizing Outstanding Ph.D. Research, |x 2190-5061 | |
| 856 | 4 | 0 | |u https://doi.uam.elogim.com/10.1007/978-3-642-23988-5 |z Texto Completo |
| 912 | |a ZDB-2-PHA | ||
| 912 | |a ZDB-2-SXP | ||
| 950 | |a Physics and Astronomy (SpringerNature-11651) | ||
| 950 | |a Physics and Astronomy (R0) (SpringerNature-43715) | ||