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Modeling Fragile X Syndrome

The present book is an in-depth synopsis of recent advances in the fragile X field. The fragile X syndrome (FXS) is the most common form of inherited mental retardation, and the molecular-genetic basis of this syndrome has been the subject of extensive experimental scrutiny over the last two decades...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Denman, Robert B. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012.
Edición:1st ed. 2012.
Colección:Results and Problems in Cell Differentiation, 54
Temas:
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Introduction: Reminiscing on Models and Modeling
  • Probing Astrocyte Function in Fragile X Syndrome
  • Neural Stem Cells
  • Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System
  • The role of the postsynaptic density in the pathology of the fragile X syndrome
  • Behavior in a Drosophila model of Fragile X
  • Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome
  • Fragile X Mental Retardation Protein and Stem Cells
  • Manipulating the Fragile Mental Retardation Proteins in the frog
  • Exploring the zebra finch Taeniopygia guttata as a novel animal model for the speech-language deficit of fragile X syndrome
  • Neuroendocrine alterations in the fragile X mouse
  • Taking STEPs forward to understanding Fragile X Syndrome
  • Fmr-1 as an offspring genetic and a maternal environmental factor in neurodevelopmental disease
  • Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome
  • Clinical Aspects of the Fragile X Syndrome
  • Fragile X Syndrome: A Psychiatric Perspective
  • Fragile X Syndrome and Targeted Treatment Trials
  • The Fragile X-associated Tremor Ataxia Syndrome
  • Vignettes: Models in Absentia.