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Phosphodiesterases as Drug Targets
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
2011.
|
| Edición: | 1st ed. 2011. |
| Colección: | Handbook of Experimental Pharmacology,
204 |
| Temas: | |
| Acceso en línea: | Texto Completo |
MARC
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| 245 | 1 | 0 | |a Phosphodiesterases as Drug Targets |h [electronic resource] / |c edited by Sharron H. Francis, Marco Conti, Miles D. Houslay. |
| 250 | |a 1st ed. 2011. | ||
| 264 | 1 | |a Berlin, Heidelberg : |b Springer Berlin Heidelberg : |b Imprint: Springer, |c 2011. | |
| 300 | |a XVIII, 522 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 490 | 1 | |a Handbook of Experimental Pharmacology, |x 1865-0325 ; |v 204 | |
| 520 | |a Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. | ||
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Medicinal chemistry. | |
| 650 | 0 | |a Proteins. | |
| 650 | 0 | |a Enzymology. | |
| 650 | 0 | |a Post-translational modification. | |
| 650 | 0 | |a Cytology. | |
| 650 | 1 | 4 | |a Pharmacology. |
| 650 | 2 | 4 | |a Medicinal Chemistry. |
| 650 | 2 | 4 | |a Proteins. |
| 650 | 2 | 4 | |a Enzymology. |
| 650 | 2 | 4 | |a Post-translational Modifications. |
| 650 | 2 | 4 | |a Cell Biology. |
| 700 | 1 | |a Francis, Sharron H. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Conti, Marco. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Houslay, Miles D. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783642179686 |
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| 830 | 0 | |a Handbook of Experimental Pharmacology, |x 1865-0325 ; |v 204 | |
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| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||